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Flavone acetic acid (LM 975, NSC 347512). A novel antitumor agent
Cancer Chemotherapy and Pharmacology
|January 1, 1987
Summary
Flavone acetic acid (FAA) shows promise as an antitumor agent in solid tumors. Animal studies suggest FAA
Area of Science:
- Biochemistry
- Pharmacology
- Oncology
Background:
- Flavone acetic acid (FAA) is a synthetic flavonoid with demonstrated antitumor activity in preclinical models.
- Its mechanism involves cytotoxic effects on cancer cells, making it a candidate for cancer therapy.
Purpose of the Study:
- To evaluate the safety and efficacy of Flavone acetic acid (FAA) in human clinical trials.
- To establish dosing and therapeutic windows for FAA based on preclinical data.
Main Methods:
- Phase I clinical trials were designed based on animal pharmacologic data.
- Studies focused on predicting cytotoxic efficacy and normal tissue toxicity.
Main Results:
- Animal studies indicated that FAA's pharmacologic behavior predicts both its effectiveness against tumors and its toxicity.
- Key toxicities observed in animals were in the central nervous system and gastrointestinal tract.
Conclusions:
- The preclinical profile of FAA supports its clinical investigation as an antitumor agent.
- Phase I studies aim to optimize FAA's safety and efficacy in cancer patients.