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Severe Acute Myocarditis after the Third (Booster) Dose of mRNA COVID-19 Vaccination

Bethlehem Mengesha1, Asen G Asenov1, Bruria Hirsh-Raccah1,2

  • 1Heart Institute, Hadassah Medical Center, Faculty of Medicine, Hebrew University of Jerusalem, Jerusalem 9112001, Israel.

Vaccines
|April 23, 2022
PubMed

Insights

The third dose of the Pfizer-BioNTech COVID-19 vaccine (BNT162b2) may be associated with severe myocarditis, a rare side effect. This case report highlights a potential risk following booster vaccinations.

Area of Science:

  • Immunology
  • Cardiology
  • Vaccinology

Background:

  • mRNA vaccines for COVID-19, like Pfizer-BioNTech's BNT162b2, have shown efficacy but are associated with rare risks of myocarditis and pericarditis.
  • Myocarditis following COVID-19 vaccination is typically observed in young males after the second dose and is usually mild.
  • Booster doses are recommended to enhance protection against SARS-CoV-2 infection and severe disease.

Observation:

  • A large national study in Israel indicated a significantly higher incidence of myocarditis post-vaccination compared to historical data.
  • Over 4.4 million individuals in Israel received the third BNT162b2 vaccine dose.
  • This report details the first histologically confirmed case of severe myocarditis after receiving the COVID-19 vaccine booster.

Findings:

  • The case involved severe myocarditis confirmed through histological examination.
  • The event occurred after the administration of the third dose of the Pfizer-BioNTech BNT162b2 vaccine.
  • This represents a rare but serious adverse event potentially linked to COVID-19 vaccine boosters.

Implications:

  • Healthcare providers should be aware of the potential for severe myocarditis following COVID-19 vaccine boosters.
  • Further research is needed to understand the incidence and risk factors for severe myocarditis after booster doses.
  • This finding may inform vaccination guidelines and patient counseling regarding potential risks and benefits of booster shots.

Keywords:
COVID-19boostermRNA vaccinationmyocarditis

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