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Related Concept Videos

Cardiopulmonary Resuscitation I: Adult01:21

Cardiopulmonary Resuscitation I: Adult

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Cardiopulmonary resuscitation, or CPR, is a life-saving emergency procedure performed when a person's heart has stopped beating or they are no longer breathing. The foundation of CPR is Basic Life Support (BLS), which focuses on the early recognition of cardiac arrest, the immediate start of high-quality chest compressions, and the timely use of an automated external defibrillator (AED).Assessing Responsiveness and Checking the Carotid PulseWhen approaching an unresponsive person, first ensure...
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Cardiopulmonary Resuscitation IV: Pharmacological Management01:25

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Pharmacologic intervention is crucial in treating cardiac arrest patients during ACLS or Advanced Cardiovascular Life Support. The ACLS algorithms guide the administration of specific drugs based on the patient's cardiac arrest rhythm, which includes pulseless ventricular tachycardia (VT), ventricular fibrillation (VF), asystole, and pulseless electrical activity (PEA).EpinephrineIndication: Epinephrine is the first-line drug for all cardiac arrest rhythms.Mechanism of Action: Epinephrine...
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Introduction to AEDAn Automated External Defibrillator (AED) is a portable medical device that analyzes the heart's rhythm and, if necessary, delivers an electrical shock to help the heart re-establish an effective rhythm during sudden cardiac arrest (SCA). SCA occurs when the heart suddenly and unexpectedly stops beating, leading to a loss of blood flow to the brain and other vital organs. In such emergencies, time is of the essence, and using an AED, combined with Cardiopulmonary...
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Cardiopulmonary Resuscitation II: ACLS Airway Management01:22

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Airway management is a key skill in emergency and critical care settings, as maintaining a clear airway is essential for adequate oxygenation and ventilation.Head Tilt-Chin Lift TechniqueThe head tilt-chin lift maneuver is an essential technique primarily used in patients without suspected cervical spine injuries. To perform this maneuver, one hand is placed on the patient’s forehead, and gentle pressure is applied backward to tilt the head. The fingertips of the other hand are positioned...
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Cardiopulmonary Resuscitation V: Advanced Airway Management Techniques01:30

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Airway management is essential in emergency and surgical medicine, ensuring ventilation and oxygenation in patients who cannot maintain their own airway. Clinicians use a range of techniques and devices to secure the airway, depending on the patient’s condition and the clinical context. Key methods include endotracheal intubation, rapid sequence intubation (RSI), supraglottic airway devices, and advanced visualization aids. In cases where these approaches fail, surgical airway...
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Related Experiment Video

Updated: Sep 26, 2025

A Rat Model of Ventricular Fibrillation and Resuscitation by Conventional Closed-chest Technique
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Making the Argument for Intact Cord Resuscitation: A Case Report and Discussion.

Judith Mercer1,2, Debra Erickson-Owens2, Heike Rabe3

  • 1Neonatal Research Institute, Sharp Mary Birch Hospital for Women and Newborns, San Diego, CA 92123, USA.

Children (Basel, Switzerland)
|April 23, 2022
PubMed
Summary

Intact cord resuscitation, by enabling placental transfusion, enhances blood volume in newborns. This supports physiologic neonatal transition, particularly for compromised infants needing resuscitation.

Keywords:
cord clampingintact cord resuscitationperfusionplacental transfusionvagus nerve

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Area of Science:

  • Neonatal Resuscitation
  • Physiology
  • Perinatal Medicine

Background:

  • Newborns requiring resuscitation often face challenges in physiologic transition.
  • Delayed or incomplete placental transfusion can exacerbate these challenges.
  • Current resuscitation practices may not fully leverage the benefits of residual placental blood volume.

Purpose of the Study:

  • To investigate the beneficial effects of enhanced blood volume from placental transfusion in newborns needing resuscitation.
  • To propose that intact cord resuscitation supports physiologic neonatal transition, especially in moribund infants.
  • To explore the mechanisms by which placental transfusion may improve neonatal outcomes.

Main Methods:

  • A case study of intact cord resuscitation was utilized.
  • The study focuses on the proposed benefits of maintaining placental circulation.
  • Physiologic parameters and clinical outcomes were observed post-intervention.

Main Results:

  • The case demonstrated improved outcomes with intact cord resuscitation.
  • Enhanced blood flow from placental transfusion likely facilitated lung vasodilatation and reduced pulmonary vascular resistance.
  • The infant regained consciousness, initiated breathing, and showed improved tone and reflexes.

Conclusions:

  • Intact cord resuscitation and placental transfusion offer significant benefits for neonatal transition.
  • This approach is particularly crucial for compromised infants requiring resuscitation.
  • Maintaining umbilical cord circulation supports physiologic adaptation in the critical first minutes of life.