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Related Concept Videos

Bone Disorders01:29

Bone Disorders

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Bone Formation by Intramembranous Ossification01:29

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Intramembranous ossification is one of the two processes involved in the development of bones within an embryo. The flat bones of the face, most of the cranial bones, and the clavicles are formed via this process. During intramembranous ossification, the bones develop directly from sheets of undifferentiated mesenchymal connective tissue.
The process begins when mesenchymal cells in the embryonic skeleton gather together and differentiate into osteogenic cells, which then develop into ...
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Bone Formation by Endochondral Ossification01:24

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Bone formation, or ossification, begins around the sixth to seventh week of embryonic development. Most bones develop from a cartilaginous template through the process of endochondral ossification. Cartilage formation begins when clusters of mesenchymal cells differentiate into chondrocytes. These chondrocytes proliferate rapidly and secrete an extracellular matrix that becomes encased in a membrane called the perichondrium. The resulting cartilage model provides a template that resembles the...
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Changes in the Appendicular Skeleton with Age01:09

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The upper and lower limb initially develops as a small bulge called a limb bud, which appears on the lateral side of the early embryo. The upper limb bud appears near the end of the fourth week of development, with the lower limb bud appearing shortly after.
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Hormones and Bone Tissue01:17

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
Hormones That Influence Osteoblasts and/or Maintain the Matrix
Several hormones are necessary for controlling bone growth and maintaining the bone matrix. The pituitary gland secretes growth hormone (GH), which, as its name implies, controls bone growth. This happens in several ways: first, it triggers chondrocyte...
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Introduction to the Skeletal System01:20

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The skeletal system is the central framework of the body, consisting of different connective tissues: bones, cartilage, tendons, and ligaments.
Components of the Skeletal System
Bone, or osseous tissue, is a hard connective tissue that forms an internal support structure for the human body. Bones shield vulnerable organs and soft tissue from external forces. For example, the vertebral bones protect and support the spinal cord.
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Bone Development and Disease in Infants.

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This special issue explores bone development and diseases in infants. It covers key research on pediatric bone health and related conditions.

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Area of Science:

  • Pediatric Orthopedics
  • Developmental Biology
  • Pediatric Endocrinology

Background:

  • Infantile bone development is crucial for skeletal health.
  • Understanding congenital and acquired bone diseases in infants is essential.
  • This special issue addresses critical knowledge gaps in pediatric bone health.

Discussion:

  • The issue covers genetic factors influencing bone formation.
  • It examines the impact of nutrition on infant skeletal development.
  • Discussions include therapeutic strategies for pediatric bone disorders.

Key Insights:

  • Early diagnosis and intervention are vital for managing infant bone diseases.
  • Novel research highlights advancements in understanding skeletal pathologies.
  • The collection emphasizes the interplay between genetics and environment in bone health.

Outlook:

  • Future research should focus on personalized treatment approaches.
  • Continued investigation into regenerative medicine for bone defects is needed.
  • This issue sets the stage for improved clinical outcomes in pediatric bone conditions.