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Assessment of Vascular Function in Patients With Chronic Kidney Disease
08:50

Assessment of Vascular Function in Patients With Chronic Kidney Disease

Published on: June 16, 2014

16.4K

Emerging Biomarkers for Early Detection of Chronic Kidney Disease

Maja Mizdrak1,2, Marko Kumrić2, Tina Tičinović Kurir2,3

  • 1Department of Nephrology and Hemodialysis, University Hospital of Split, 21000 Split, Croatia.

Journal of Personalized Medicine
|April 23, 2022
PubMed

Insights

Early detection of chronic kidney disease (CKD) is crucial but hindered by a lack of ideal biomarkers. This review explores current and emerging diagnostic methods for prompt CKD identification and management.

Area of Science:

  • Nephrology
  • Biomarker Discovery
  • Diagnostic Methods

Background:

  • Chronic kidney disease (CKD) is a significant global health issue affecting over 10% of the population.
  • Early diagnosis and treatment are vital to prevent kidney function decline and adverse outcomes.
  • Current diagnostic methods, including serum creatinine and albuminuria, have limitations in early detection.

Purpose of the Study:

  • To provide a comprehensive overview of diagnostic methods for the early detection of CKD.
  • To discuss various markers of kidney injury, including glomerular and tubulointerstitial markers.
  • To explore the potential of novel approaches like omics, microbiota, and microRNA in early CKD diagnosis.

Main Methods:

  • Review of existing literature on CKD diagnostic methods.
  • Analysis of biomarkers for glomerular and tubulointerstitial injury.
  • Evaluation of emerging technologies such as omics, microbiota analysis, and microRNA profiling.

Main Results:

  • Current biomarkers like serum creatinine and cystatin C are insufficient for early CKD detection.
  • Markers of proximal tubule injury, including kidney injury molecule-1 (KIM-1), neutrophil gelatinase-associated lipocalin (NGAL), and liver fatty acid-binding protein (L-FABP), show promise.
  • Despite advancements, no single biomarker currently meets the criteria for an ideal early-detection marker for CKD.

Conclusions:

  • There is an urgent need for novel, noninvasive, and predictive biomarkers for early CKD detection.
  • Proximal tubule injury markers are central to understanding CKD progression.
  • Further research into omics, microbiota, and microRNA is essential for developing ideal early diagnostic tools for CKD.
Keywords:
biomarkerchronic kidney diseasediagnosisearly detection

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