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Related Experiment Video

Updated: Sep 26, 2025

Integration of Wet and Dry Bench Processes Optimizes Targeted Next-generation Sequencing of Low-quality and Low-quantity Tumor Biopsies
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Analyzing Precision Medicine Utilization with Real-World Data: A Scoping Review.

Michael P Douglas1, Anika Kumar2

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|April 23, 2022
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Summary

This study reviewed real-world data sources used to track precision medicine (PM) test utilization. Registry databases and insurer claims are common, with most studies focusing on cancer applications.

Keywords:
precision medicinereal-world dataregistryscoping reviewutilization

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Area of Science:

  • Genomic Medicine
  • Health Services Research

Background:

  • Precision medicine (PM), particularly genetic testing, is increasingly used in clinical practice.
  • Databases like the NIH Genetic Testing Registry show test availability, but usage extent is unclear.
  • Real-world data (RWD) is needed to understand PM test utilization and inform appropriate use.

Purpose of the Study:

  • To conduct a scoping review of RWD sources used in studies of PM utilization.
  • To characterize the use of various sequencing-based tests between January 2015 and August 2021.
  • To identify common RWD sources and application areas for PM tests.

Main Methods:

  • Scoping review of peer-reviewed literature.
  • Search conducted for studies published between January 2015 and August 2021.
  • Included studies characterizing the use of genome sequencing (GS), exome sequencing (ES), tumor sequencing (TS), next-generation sequencing (NGS), gene expression profiling (GEP), and pharmacogenomics (PGx) panels.

Main Results:

  • 72 articles were included from 440 identified.
  • Registry databases and private insurer claims were the most common RWD sources.
  • 67% of studies focused on oncological applications; 38% used integrated datasets.

Conclusions:

  • This review summarizes RWD sources used in PM utilization literature.
  • Findings can inform future study designs by promoting centralized databases and registries.
  • Improved tracking of PM implementation and use is recommended.