Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Osteogenesis imperfecta. The set point proposal (a possible causative mechanism).

H M Frost

    Clinical Orthopaedics and Related Research
    |March 1, 1987
    PubMed
    Summary

    The minimum effective strain (MES) is a threshold for tissue strain. An elevated MES may explain bone fragility and tissue abnormalities seen in osteogenesis imperfecta.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The surgical technique for forequarter amputation: a clinical analysis of ten cases.

    Orthopedics·2014
    Same author

    The Response of Cardio-Vascular System to Respiratory Exertion.

    Transactions of the American Climatological and Clinical Association. American Climatological and Clinical Association·2011
    Same author

    New targets for fascial, ligament and tendon research: a perspective from the Utah paradigm of skeletal physiology.

    Journal of musculoskeletal & neuronal interactions·2005
    Same author

    Perspective: genetic and hormonal roles in bone disorders: insights of an updated bone physiology.

    Journal of musculoskeletal & neuronal interactions·2005
    Same author

    On the strength-safety factor (SSF) for load-bearing skeletal organs.

    Journal of musculoskeletal & neuronal interactions·2005
    Same author

    On the pathogenesis of osteogenesis imperfecta: some insights of the Utah paradigm of skeletal physiology.

    Journal of musculoskeletal & neuronal interactions·2005

    Area of Science:

    • Biomechanics
    • Skeletal Biology
    • Pathophysiology

    Background:

    • The minimum effective strain (MES) is a critical threshold for bone and soft tissue adaptation.
    • Strains exceeding the MES trigger modeling and remodeling to restore the threshold.
    • Abnormalities in tissue structure and fragility may arise from altered strain thresholds.

    Purpose of the Study:

    • To explore the role of the minimum effective strain (MES) in bone and soft tissue development.
    • To investigate if an elevated MES set point is a potential pathogenetic factor in osteogenesis imperfecta.

    Main Methods:

    • Conceptual analysis of biomechanical principles governing tissue adaptation.
    • Correlation of MES set point effects with known clinical manifestations of osteogenesis imperfecta.

    Main Results:

    • An elevated MES threshold could lead to reduced tissue thickness and bone density.
    • Predicted outcomes of an elevated MES align with observed abnormalities in osteogenesis imperfecta patients.
    • This suggests a potential link between MES and the disease's pathogenesis.

    Conclusions:

    • An elevated minimum effective strain (MES) set point is a plausible contributing factor to osteogenesis imperfecta.
    • Further research is warranted to validate the role of MES in this genetic disorder.

    Related Experiment Videos