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Cardiovascular Risks in Korean Patients with Gout: Analysis Using a National Health Insurance Service Database

Ki Won Moon1, Min Jung Kim2, In Ah Choi3

  • 1Division of Rheumatology, Department of Internal Medicine, Kangwon National University School of Medicine, Chuncheon 24289, Korea.

Journal of Clinical Medicine
|April 23, 2022
PubMed

Insights

Gout patients face higher risks of heart attack and stroke. Managing traditional cardiovascular risk factors and lowering urate levels is crucial for these individuals.

Area of Science:

  • Cardiology
  • Rheumatology
  • Epidemiology

Background:

  • Gout is linked to cardiovascular diseases, but specific risk factors in Asian populations remain unclear.
  • Understanding these risks is vital for effective patient management.

Purpose of the Study:

  • To investigate cardiovascular outcome risks and related factors in Korean gout patients.
  • To identify specific risk factors contributing to cardiovascular disease in this demographic.

Main Methods:

  • Retrospective cohort study using National Health Insurance Service data from Korea.
  • Gout patients (ICD-10 code M10) were compared to matched controls.
  • Cox regression analysis adjusted for confounders to determine hazard ratios for cardiovascular events.

Main Results:

  • Gout patients showed significantly increased risks of ischemic heart disease (HR: 1.860), acute myocardial infarction (HR: 3.246), and cerebrovascular disease (HR: 1.552).
  • Factors like older age, smoking, alcohol use, high LDL, and diabetes mellitus elevated cardiovascular risk.
  • Hypouricemic agents were associated with a reduced risk of cerebrovascular diseases.

Conclusions:

  • Gout is an independent risk factor for major cardiovascular outcomes.
  • Comprehensive management including addressing traditional cardiovascular risk factors and urate-lowering therapy is essential for gout patients.

Keywords:
cerebrovascular diseasegouturate lowering therapy

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