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Impact of Deprivation on Obesity in Children with PWS

Sabrina Grolleau1, Marine Delagrange1, Melina Souquiere1

  • 1French Reference Centre for Prader-Willi Syndrome and Other Rare Forms of Obesity with Eating Disorders, CHU Toulouse, 31059 Toulouse, France.

Journal of Clinical Medicine
|April 23, 2022
PubMed

Insights

Social deprivation significantly increases obesity risk in children with Prader-Willi syndrome (PWS). Early identification and intervention for at-risk families are crucial for preventing childhood obesity.

Area of Science:

  • Pediatrics
  • Endocrinology
  • Public Health

Background:

  • Prader-Willi syndrome (PWS) is a complex genetic disorder associated with hyperphagia and obesity.
  • Social determinants of health, including deprivation, can significantly impact health outcomes in children with chronic conditions.

Purpose of the Study:

  • To evaluate the social deprivation score in families of children with PWS.
  • To analyze the impact of social deprivation on the occurrence of obesity in children with PWS.

Main Methods:

  • A cohort of 147 children with PWS was assessed using the EPICES score for social deprivation.
  • Statistical analyses, including multivariate logistic regression, were employed to identify risk factors for obesity.

Main Results:

  • 25.9% of families with children with PWS experienced social deprivation.
  • Obese children with PWS were more likely to come from deprived families (50.0% vs. 18.0%) and have obese mothers (46.9% vs. 13.3%).
  • Age, family social deprivation, and maternal obesity were significant predictors of obesity in children with PWS.

Conclusions:

  • Risk factors for obesity in children with PWS mirror those in the general population.
  • Early identification of families facing social deprivation is essential for targeted obesity prevention strategies in PWS.
  • Reinforced interventions are needed for at-risk families to mitigate obesity development in children with PWS.

Keywords:
Prader–Willi syndromedeprivationobesitysocioeconomic status

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