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Serum Asprosin Concentrations in Children with Prader-Willi Syndrome: Correlations with Metabolic Parameters

Maha Alsaif1, Catherine J Field1, Eloisa Colin-Ramirez2,3

  • 1Department of Agricultural, Food and Nutritional Science, University of Alberta, Edmonton, AB T6G 2R7, Canada.

Journal of Clinical Medicine
|April 23, 2022
PubMed

Insights

Asprosin levels did not differ in children with Prader-Willi syndrome (PWS) compared to controls. However, fasting asprosin correlated with glucose in obese children, suggesting a potential predictor for metabolic changes.

Area of Science:

  • Endocrinology
  • Pediatric Obesity
  • Metabolic Syndrome

Background:

  • Prader-Willi syndrome (PWS) is associated with severe obesity.
  • Asprosin, a protein hormone from white adipose tissue, is linked to insulin resistance.

Purpose of the Study:

  • To compare serum asprosin concentrations in children with PWS, overweight/obesity, and normal weight.
  • To investigate postprandial asprosin changes in PWS and matched controls.

Main Methods:

  • Enrolled 52 children: 23 with PWS, 8 overweight/obese, 21 normal weight.
  • Measured fasting asprosin, glucose, insulin, HOMA-IR, acyl ghrelin, and leptin.
  • Assessed postprandial asprosin in a subsample.

Main Results:

  • No significant differences in fasting asprosin, glucose, insulin, or HOMA-IR across groups.
  • No differences in fasting or postprandial asprosin in PWS or control groups.
  • Fasting asprosin correlated positively with glucose in obese children (p=0.007).

Conclusions:

  • Asprosin may predict early glucose metabolism alterations in obese children.
  • Further research is needed on asprosin's role in PWS metabolism and obesity.

Keywords:
glucose metabolisminsulin resistancesyndromic obesity

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