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Accelerated Type 1 Diabetes Induction in Mice by Adoptive Transfer of Diabetogenic CD4+ T Cells
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Fighting Enteroviral Infections to Prevent Type 1 Diabetes

Magloire Pandoua Nekoua1, Ambroise Mercier1, Abdulaziz Alhazmi1,2

  • 1Laboratoire de Virologie ULR3610, Université de Lille, CHU Lille, 59000 Lille, France.

Microorganisms
|April 23, 2022
PubMed

Insights

Enteroviruses, particularly coxsackieviruses B, may trigger type 1 diabetes (T1D) in susceptible individuals. Antiviral drugs and vaccines show promise for preventing T1D by combating these viral infections.

Area of Science:

  • Virology
  • Immunology
  • Endocrinology

Background:

  • Enteroviruses (EVs), especially coxsackieviruses B (CVB), are implicated in triggering or accelerating islet autoimmunity.
  • This autoimmune process in genetically susceptible individuals can lead to type 1 diabetes (T1D).

Purpose of the Study:

  • To highlight the need for strategies to combat EV infections.
  • To review potential antiviral therapies and vaccines for CVB infections.

Main Methods:

  • Review of existing research on enteroviruses and type 1 diabetes.
  • Analysis of current antiviral drug development and vaccine research targeting CVB.

Main Results:

  • No approved antiviral drugs are currently available for EV infections.
  • Emerging antiviral drugs and vaccines show potential in combating CVB.

Conclusions:

  • Antiviral strategies targeting viral or host cell proteins offer potential therapeutic options.
  • These strategies may prevent or reduce the risk of T1D and preserve beta-cell function in at-risk individuals.
Keywords:
antiviralcoxsackievirusenterovirusestype 1 diabetesvaccine

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