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Related Concept Videos

Drug Delivery: Overview01:16

Drug Delivery: Overview

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The selection of a drug's delivery route depends upon its physicochemical properties, including lipid or water solubility and ionization, as well as the therapeutic requirement, such as immediate or sustained effect. These routes can be divided into three primary categories: enteral, parenteral, and topical.
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
495
Factors Influencing Drug Absorption: Pharmaceutical Parameters01:28

Factors Influencing Drug Absorption: Pharmaceutical Parameters

205
Solid dosage forms such as tablets and capsules undergo rigorous manufacturing processes to ensure stability and effectiveness. Their dissolution and absorption properties are influenced significantly by the choice of excipients (inactive ingredients that serve various roles in the formulation), and the methodology applied during production. The manufacturing parameters, such as compression force and granulation techniques, significantly affect dissolution rates. Elevated compression forces...
205
Drug Delivery: Enteral Route01:18

Drug Delivery: Enteral Route

801
The enteral drug administration involves three primary routes: oral, sublingual, and buccal. Oral ingestion is the most prevalent, safe, economical, and convenient method for drug administration. However, it has certain drawbacks, including limited absorption due to the drug's low water solubility or poor membrane permeability, possible emesis from GI mucosa irritation, destruction of drugs by digestive enzymes or low gastric pH, and irregular absorption along with food or other drugs.
801
Drug Delivery: Parenteral Route01:29

Drug Delivery: Parenteral Route

936
The parenteral route is a critical method of drug administration. It delivers compounds directly into the systemic circulation and bypasses the gastrointestinal tract. This approach is particularly advantageous for drugs that exhibit poor absorption or instability when administered orally.
There are three primary parenteral routes: intravenous (IV), intramuscular (IM), and subcutaneous (SC). The IV route introduces the drug directly into the bloodstream, ensuring immediate action. The IM route...
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Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

1.1K
Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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Nutraceutical Concepts and Dextrin-Based Delivery Systems.

Gjylije Hoti1, Adrián Matencio1, Alberto Rubin Pedrazzo1

  • 1Department of Chemistry, University of Torino, Via P. Giuria 7, 10125 Torino, Italy.

International Journal of Molecular Sciences
|April 23, 2022
PubMed
Summary
This summary is machine-generated.

Cyclodextrin (CD)-based nanosponges (NSs) enhance nutraceutical delivery by overcoming poor solubility and low bioavailability. These advanced nanocarriers improve stability and controlled release of health-promoting compounds.

Keywords:
cyclic dextrindiseasedrug deliverylinear dextrinnano-carriernanospongesnutraceutical deliverynutraceuticalsstarch

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Area of Science:

  • Nanotechnology and Materials Science
  • Pharmacology and Drug Delivery
  • Nutraceutical Science

Background:

  • Nutraceuticals offer health benefits but face limitations like poor solubility and bioavailability.
  • Nanotechnology provides solutions to enhance nutraceutical efficacy and delivery.
  • Cyclodextrins (CDs) and their derivatives, like nanosponges (NSs), are promising nanomaterials for this purpose.

Purpose of the Study:

  • To review the application of cyclodextrin-based nanosponges for nutraceutical delivery.
  • To highlight the advantages of CD-based NSs over traditional delivery systems.
  • To discuss the synthesis, characterization, and application pathways of CD-based nanosystems.

Main Methods:

  • Literature review focusing on cyclodextrin-based nanosponges and nutraceutical delivery.
  • Analysis of studies on the use of CD-based NSs for compounds like quercetin, curcumin, and resveratrol.
  • Examination of the properties and performance of CD-based NSs compared to inclusion complexes and uncomplexed nutraceuticals.

Main Results:

  • CD-based nanosponges significantly improve solubility, stability, and bioavailability of poorly water-soluble nutraceuticals.
  • CD-based NSs offer controlled and prolonged release of active compounds.
  • These nanocarriers demonstrate higher biocompatibility compared to other delivery systems.

Conclusions:

  • Cyclodextrin-based nanosponges represent an advanced and effective system for nutraceutical delivery.
  • Further development of CD-based nanosystems, including those based on linear dextrins, holds significant potential for enhancing health outcomes.
  • This review provides a comprehensive overview for the advancement of nutraceutical delivery systems.