Related Experiment Video
Updated: Sep 26, 2025
07:36
Clinical Application of Intense Pulsed Light Therapy and Radio Frequency for Treatment of Ocular Surface Diseases
Published on: July 3, 2025
235
Vitamin D and Ocular Diseases: A Systematic Review
Hei-Nga Chan1, Xiu-Juan Zhang1, Xiang-Tian Ling1
1Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China.
International Journal of Molecular Sciences
|April 23, 2022
Summary
Vitamin D deficiency is linked to several eye conditions, including myopia, age-related macular degeneration (AMD), diabetic retinopathy (DR), and dry eye syndrome (DES). Further research is needed for conditions like glaucoma and thyroid eye disease (TED).
Area of Science:
- Ophthalmology
- Endocrinology
- Nutritional Science
Background:
- Vitamin D plays a role in ocular and visual health.
- Vitamin D deficiency is associated with adverse effects on the eyes.
- Numerous studies explore the link between vitamin D and various eye diseases.
Purpose of the Study:
- To systematically review recent findings on the association between vitamin D and ocular diseases.
- To discuss vitamin D metabolism in the eye.
- To evaluate the evidence for vitamin D's role in conditions like myopia, AMD, DR, DES, glaucoma, and others.
Main Methods:
- Systematic review of recent findings.
- Searched two research databases for relevant articles.
- Included epidemiological, clinical, and basic studies.
Main Results:
- 162 studies were identified and reviewed.
- Evidence supports an association between vitamin D and myopia, AMD, DR, and DES.
- Strong evidence links vitamin D to DR (48/54 studies) and DES (25/27 studies), and moderate evidence for AMD (17/27 studies).
Conclusions:
- Vitamin D deficiency is associated with several common ocular diseases.
- The evidence for vitamin D's role in conditions like glaucoma, TED, and RB is currently limited.
- Further investigation is warranted to fully elucidate vitamin D's impact on eye health.
Keywords:
age-related macular degenerationdry eye syndromeglaucomamyopiaocular diseaseretinoblastomathyroid eye diseaseuveitisvitamin Dvitamin D receptorMore Related Videos
05:03Author Spotlight: Investigating Physiological Functions of Vitamin A Transporters Using HPLC-Based Vitamin A Profiling
Published on: December 27, 2024
1.3K
06:29Comparing Objective Conjunctival Hyperemia Grading and the Ocular Surface Disease Index Score in Dry Eye Syndrome During COVID-19
Published on: May 25, 2022
2.5K
Related Concept Videos
01:22Connective Tissue Cell Types
3.5K
Connective tissue develops from the mesoderm of a developing embryo and consists of cells, fibers, and ground substance: a gel-like material containing large complexes of carbohydrates and proteins. Connective tissue was first identified as a separate tissue family in the 18th century, and Johannes Peter Muller coined the term connective tissue.
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
Fat cells (adipocytes), smooth muscle cells (myoblasts), and bone cells (osteoblasts) are some connective tissue cell types. Some immune system cells...
3.5K
01:22Photoreceptors and Visual Pathways
6.6K
At the molecular level, visual signals trigger transformations in photopigment molecules, resulting in changes in the photoreceptor cell's membrane potential. The photon's energy level is denoted by its wavelength, with each specific wavelength of visible light associated with a distinct color. The spectral range of visible light, classified as electromagnetic radiation, spans from 380 to 720 nm. Electromagnetic radiation wavelengths exceeding 720 nm fall under the infrared category,...
6.6K
01:25Glaucoma: Overview
910
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
910
01:27Open Angle Glaucoma: Treatment
708
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
Drugs such as carbonic anhydrase inhibitors, α2- and...
708
01:28Angle Closure Glaucoma: Treatment
832
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
832
01:17Accessory Structures of the Eye
2.0K
Optical perception, or vision, is an extraordinary sense dependent on converting light signals received via the ocular organs. These organs, known as eyes, are securely positioned within the bony cavities of the skull, called orbits. The orbits serve a dual purpose: a protective shield for the ocular globes and a stable attachment point for the soft ocular tissues. The eye's external protective mechanisms include the eyelids, which are edged with lashes that act as a barrier against foreign...
2.0K