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Author Spotlight: In Vivo Assessment of Thyroid Hormone Disruption Using the THAI Mouse Model
Published on: October 6, 2023
Uncontrolled Thyroid during Pregnancy Alters the Circulative and Exerted Metabolome
Charalambos Fotakis1, Giorgos Moros1, Anna Kontogeorgou2
1Institute of Chemical Biology, National Hellenic Research Foundation, 48 Vas. Constantinou Ave., 11635 Athens, Greece.
Thyroid dysfunction during pregnancy alters maternal metabolism, affecting lipid and glucose pathways. Even with treatment, a distinct metabolic profile persists, highlighting the need for ongoing monitoring in hypothyroid women.
Area of Science:
- Endocrinology
- Metabolomics
- Pregnancy Health
Background:
- Thyroid hormones (THs) are crucial for fetal development and maternal health.
- Hypothyroidism during pregnancy can lead to cognitive impairments and metabolic disturbances.
Purpose of the Study:
- To investigate metabolic profiles in pregnant women with thyroid dysfunction.
- To assess if thyroxine replacement therapy normalizes metabolic profiles.
- To analyze both circulating (serum) and excreted (colostrum) metabolic patterns.
Main Methods:
- Nuclear Magnetic Resonance (NMR) metabolomics applied to 90 maternal serum and colostrum samples.
- Multivariate statistical, biomarker, and pathway analyses of metabolomics data.
Main Results:
- Hypothyroidism significantly impacts metabolite composition in pregnant and lactating women.
- Altered metabolic profiles affect lipid and glucose pathways, potentially impacting neurodevelopment.
- Women on thyroxine replacement therapy exhibit a distinct metabolic phenotype compared to euthyroid individuals.
Conclusions:
- Thyroid dysfunction, even when treated, alters maternal metabolic pathways.
- These alterations may increase the risk for metabolic syndrome and neurodegenerative diseases.
- Continuous monitoring of hypothyroid women post-treatment initiation is essential.
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