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Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

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Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
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T Cell Types and Functions01:24

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When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
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Chronic Bowel Disorders: Introduction01:17

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
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Autoimmune Disorders01:29

Autoimmune Disorders

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Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
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The immune...
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Inflammatory Bowel Disease II: Crohn's Disease01:30

Inflammatory Bowel Disease II: Crohn's Disease

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Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
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Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

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Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
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Related Experiment Video

Updated: Sep 26, 2025

Author Spotlight: Self-Assessment Protocol for Predicting Psoriatic Arthritis in Psoriasis Patients
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Psoriasis and Systemic Inflammatory Disorders.

Tomoko Tashiro1, Yu Sawada1

  • 1Department of Dermatology, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan.

International Journal of Molecular Sciences
|April 23, 2022
PubMed
Summary
This summary is machine-generated.

Psoriasis, a skin inflammatory disease, can affect organs throughout the body. This review explores psoriasis

Keywords:
IL-17TNF-αinflammationorganspsoriasis

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Area of Science:

  • Dermatology and Immunology
  • Systemic Inflammatory Diseases

Background:

  • Psoriasis is a chronic inflammatory skin condition with significant surface area involvement.
  • Systemic circulation of inflammatory cells and cytokines suggests potential impacts on various organs.
  • Growing evidence highlights the interaction between psoriasis and systemic inflammatory diseases.

Purpose of the Study:

  • To review systemic inflammatory diseases associated with psoriasis.
  • To elucidate the molecular mechanisms underlying these associations.
  • To emphasize the role of systemic therapy in managing severe psoriasis and preventing systemic complications.

Main Methods:

  • Literature review of clinical and experimental studies.
  • Analysis of molecular pathways linking psoriasis to systemic conditions.
  • Synthesis of current understanding on psoriasis comorbidities.

Main Results:

  • Psoriasis is linked to several systemic inflammatory diseases.
  • Specific molecular mechanisms mediate the systemic effects of psoriasis.
  • Systemic therapies are crucial for managing severe psoriasis and its systemic manifestations.

Conclusions:

  • Psoriasis is not limited to the skin; it has systemic implications.
  • Understanding the molecular basis is key to managing associated inflammatory diseases.
  • Early and effective systemic treatment is vital for patients with severe psoriasis.