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Related Experiment Video

Updated: Sep 26, 2025

Fabricating High-viscosity Droplets using Microfluidic Capillary Device with Phase-inversion Co-flow Structure
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Single Microdroplet Breakup-Assisted Viscosity Measurement.

Yeongseok Jang1, Hwabok Wee2, Jonghyun Oh3

  • 1Department of Mechanical Design Engineering, Jeonbuk National University, Jeonju 54896, Korea.

Micromachines
|April 23, 2022
PubMed
Summary

This study introduces a new method using microdroplets to measure the viscosity of hydrogel prepolymers. This technique accurately predicts fluid viscosity, aiding in biomedical applications like tissue regeneration.

Keywords:
biopolymer viscositymicrodropletmicroviscometershear-thinning liquid

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Area of Science:

  • Biomedical Engineering
  • Materials Science

Background:

  • Viscosity of prepolymer fluids like hydrogels is critical for extracellular matrix (ECM) mechanical properties and cell viability.
  • Developing technologies for precise viscosity measurement is essential in biomedical fields.

Purpose of the Study:

  • To present a novel method for measuring the viscosity of trace amounts of prepolymer fluids.
  • To propose and validate a predictive equation for fluid viscosity based on microfluidic measurements.

Main Methods:

  • Utilized a flow-focused microdroplet generator to measure fluid viscosity.
  • Analyzed the break-up length of the dispersed phase in relation to flow rate and viscosity.
  • Developed and applied a viscosity prediction formula using alginate and gelatin methacryloyl (GelMA) prepolymers.

Main Results:

  • Break-up length increased with higher flow rates and viscosity.
  • The derived viscosity formula accurately predicted viscosity for alginate and GelMA.
  • An empirical formula for alginate showed less than 2% error in predicting viscosity at a flow rate of 400 uL/h.

Conclusions:

  • The developed microfluidic method offers a reliable way to measure dynamic viscosity of prepolymers using small sample volumes.
  • This technology can significantly aid in hydrogel tuning for biomedical and tissue regeneration applications.