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Curcumae Radix Decreases Neurodegenerative Markers through Glycolysis Decrease and TCA Cycle Activation.

Seong-Lae Jo¹, Hyun Yang², Sang R Lee¹

¹College of Veterinary Medicine, Chungnam National University, Daejeon 34134, Korea.

|April 23, 2022

Summary

This summary is machine-generated.

Curcumae radix extract (CRE) may improve brain health by modulating energy metabolism. This study found CRE reduced Alzheimer's markers and endoplasmic reticulum stress, while enhancing mitochondrial function in cells and animal models.

Keywords:

Alzheimer’s disease Curcumae radix TCA cycle glycolysis neurodegenerative disease

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Area of Science:

Neuroscience
Metabolic research
Pharmacology

Background:

Neurodegenerative diseases (ND) are a growing concern with aging populations.
Curcumae radix (CRE) shows potential benefits but its role in ND energy metabolism is unclear.

Purpose of the Study:

To investigate the relationship between Curcumae radix extract (CRE) and energy metabolism in neurodegenerative diseases (ND).
To evaluate CRE's effects on neurodegenerative markers and cellular metabolism.

Main Methods:

Utilized cell and animal models of ND.
Assessed neurodegenerative markers and metabolic indicators via Western blotting and qRT-PCR.
Performed cellular glycolysis and metabolic flux assays.

Main Results:

CRE treatment reduced Alzheimer's disease markers in mouse brains.
Decreased neurodegenerative and endoplasmic reticulum (ER) stress markers were observed.
CRE decreased glycolysis and extracellular acidification rate.
Increased mitochondrial Tricarboxylic acid (TCA) cycle and Oxidative phosphorylation (OXPHOS) gene expression was noted.

Conclusions:

Curcumae radix extract (CRE) may serve as a metabolic modulator for brain health.
CRE shows potential in treating and preventing neurodegenerative diseases (ND) linked to mitochondrial dysfunction.