Temperature/pH-Responsive Carboxymethyl Cellulose/Poly (N-isopropyl acrylamide) Interpenetrating Polymer Network Aerogels for Drug Delivery Systems
Zhongming Liu1,2, Sufeng Zhang2, Chao Gao1
1State Key Laboratory of Biobased Material and Green Papermaking, Key Laboratory of Pulp and Paper Science & Technology of Ministry of Education/Shandong Province, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250353, China.
Abstract:
Temperature/pH-responsive carboxymethyl cellulose/poly (N-isopropyl acrylamide) interpenetrating polymer network (IPN) aerogels (CMC/Ca2+/PNIPAM aerogels) were developed as a novel drug delivery system. The aerogel has a highly open network structure with a porosity of more than 90%, which provides convenient conditions for drug release. The morphology and structure of the CMC/Ca2+/PNIPAM aerogels were characterized via scanning electron microscopy (SEM), Micro-CT, X-ray photoelectron spectroscopy (XPS), pore size analysis, and cytotoxicity analysis. The analysis results demonstrate that the aerogel is non-toxic and has more active sites, temperatures, and pH response performances. The anticancer drug 5-fluorouracil (5-FU) was successfully loaded into aerogels through physical entrapment and hydrogen bonding. The drug loading and sustained-release model of aerogels are used to fit the drug loading and sustained-release curve, revealing the drug loading and sustained-release mechanism, and providing a theoretical basis for the efficient drug loading and sustained release.
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