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Anatomic and physiologic age changes in the kidney.

R D Lindeman, R Goldman

    Experimental Gerontology
    |January 1, 1986
    PubMed
    Summary
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    Kidney function declines progressively with age after 40. This review examines age-related changes in renal morphology and physiology, exploring the mechanisms behind these functional losses.

    Area of Science:

    • Nephrology
    • Gerontology
    • Physiology

    Background:

    • Cross-sectional studies show a progressive decline in human renal function after age 40.
    • Aging affects renal blood vessels, glomeruli, tubules, and interstitium, often leading to nephron destruction in chronic conditions.

    Purpose of the Study:

    • To review descriptive studies on age-related changes in renal morphology and physiology.
    • To focus on the mechanisms underlying age-associated losses in renal substance and function.

    Main Methods:

    • Review of existing cross-sectional studies on renal function and aging.
    • Analysis of literature on pathological processes affecting the aging kidney.

    Main Results:

    • Renal function shows a consistent decline after age 40.

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  • Multiple nephron components are implicated in the aging process and renal disease.
  • The exact cause of age-related decline (pathologic vs. involutional) remains debated.

    • Conclusions:

    • Age-related decline in renal function is well-documented.
    • Understanding the mechanisms of renal aging is crucial for managing kidney health in older adults.