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Solid-phase Synthesis of [4.4] Spirocyclic Oximes
Published on: February 6, 2019
Mechanochemical Dimerization of Aldoximes to Furoxans
Run-Kai Fang1, Kuan Chen1, Chuang Niu1
1Hefei National Laboratory for Physical Sciences, Microscale and Department of Chemistry, University of Science and Technology of China, Hefei 230026, China.
Abstract:
Solvent-free mechanical milling is a new, environmentally friendly and cost-effective technology that is now widely used in the field of organic synthesis. The mechanochemical solvent-free synthesis of furoxans from aldoximes was achieved through dimerization of the in situ generated nitrile oxides in the presence of sodium chloride, Oxone and a base. A variety of furoxans was obtained with up to a 92% yield. The present protocol has the advantages of high reaction efficiency and mild reaction conditions.
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