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Human kidney preservation by flushing with intracellular solution and cold storage.
Archives of Surgery (Chicago, Ill. : 1960)
|July 1, 1978
Summary
Collins C2 solution safely extends human kidney preservation beyond 24 hours for transplantation. This study shows comparable graft function for extended cold storage, improving organ availability.
Area of Science:
- Nephrology
- Transplantation Medicine
- Organ Preservation
Background:
- Traditional methods for human kidney preservation are limited to 24 hours.
- Extending preservation time is crucial for increasing organ availability and improving transplant outcomes.
Purpose of the Study:
- To evaluate the efficacy of Collins C2 solution for extending human kidney preservation time.
- To assess the impact of extended cold storage on immediate and long-term kidney graft function.
Main Methods:
- A prospective study involving 25 primary cadaver kidney transplants.
- Kidneys were preserved using Collins C2 solution followed by simple cold storage.
- Preservation times were divided into two groups: 10-23 hours and 26-44.5 hours.
Main Results:
- Sixty-eight percent of kidneys exhibited immediate, sustained function.
- The one-month graft function rate was 88%.
- No significant differences were observed between short-term and extended preservation groups regarding dialysis, one-month function, or serum creatinine levels.
Conclusions:
- Collins C2 solution enables safe extension of human kidney preservation beyond 24 hours.
- Extended cold storage does not adversely affect early or one-month graft function.
- This approach can enhance the viability of donor kidneys for transplantation.