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Two new chromanone acids from the stem bark of Calophyllum peekelii Lauterb
Tjitjik Srie Tjahjandarie1, Wisnu Aji Setyo Nugroho1, Hady Palgunadi1
1Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia.
Abstract:
Three chromanone acids were isolated from the stem bark of Calophyllum peekelii Lauterb. Among them are two new chromanone acids, calopeekelioic acids A (1) and B (2), along with calolongic acid (3), Their structures were established by analyzing a combination of HRESIMS, 1 D, and 2 D NMR spectra. Chromanone acids 1-3 were evaluated for their antiplasmodial activity against Plasmodium falciparum strain 3D7. Compounds 1-2 showed high activity with an IC50 value of 1.70 and 1.01 µg/mL, respectively.
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