Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Thrombosis and cancer.

H F Dvorak

    Human Pathology
    |March 1, 1987
    PubMed
    Summary
    This summary is machine-generated.

    Malignant diseases cause abnormal blood clotting (hemostasis) by tumor cells initiating coagulation both inside and outside blood vessels. This abnormal clotting impacts tumor growth, immune response, and blood vessel formation.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Granulocytes (the red, white, and blue) in hypersensitivity reactions: A review.

    Inflammation·2013
    Same author

    Fibronectin beneath reepithelializing epidermis in vivo: sources and significance.

    The Journal of investigative dermatology·2010
    Same author

    Why are tumour blood vessels abnormal and why is it important to know?

    British journal of cancer·2009
    Same author

    Angiogenesis: update 2005.

    Journal of thrombosis and haemostasis : JTH·2005
    Same author

    VEGF-A angiogenesis induces a stable neovasculature in adult murine brain.

    Journal of neuropathology and experimental neurology·2004
    Same author

    VEGF-A induces angiogenesis, arteriogenesis, lymphangiogenesis, and vascular malformations.

    Cold Spring Harbor symposia on quantitative biology·2003

    Area of Science:

    • Oncology
    • Hematology
    • Pathology

    Background:

    • Abnormal hemostasis is intrinsically linked to malignant diseases, not solely a consequence of treatment or illness.
    • Tumor cells actively participate in hemostasis by expressing clotting factors and providing surfaces for coagulation cascade activation.

    Purpose of the Study:

    • To elucidate the mechanisms by which malignant tumors induce and interact with the hemostatic system.
    • To understand the role of tumor-associated procoagulants in both intravascular and extravascular clotting.
    • To explore the consequences of tumor-induced fibrin deposition on the tumor microenvironment.

    Main Methods:

    • Analysis of tumor cell expression of procoagulant factors (e.g., tissue factor).
    • Investigation of tumor-induced microvascular hyperpermeability.

    Related Experiment Videos

  • Assessment of fibrin deposition and turnover within solid tumors.
  • Evaluation of the impact of abnormal clotting on tumor immunology and angiogenesis.

    • Main Results:

    • Tumor cells express tissue factor, initiating intravascular clotting upon entering circulation.
    • Solid tumors induce microvascular leakage, allowing plasma proteins to enter tissues and promote local clotting.
    • Rapid fibrin deposition and turnover occur within tumors, both intra- and extravascularly.
    • Tumor-associated fibrin deposition influences inflammatory cell infiltration, immune responses, and angiogenesis.

    Conclusions:

    • Abnormal hemostasis is a fundamental aspect of cancer biology, driven by tumor cell procoagulant activity.
    • Tumor-induced fibrin deposition plays a critical role in shaping the tumor microenvironment and facilitating tumor progression.
    • Understanding these hemostatic alterations is crucial for developing novel cancer therapies.