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Updated: Sep 26, 2025

Hierarchical and Programmable One-Pot Oligosaccharide Synthesis
Published on: September 6, 2019
Synthesis of selenoglycosides and selenium linked disaccharides using reductive cleavage of diselenides
Pradip Shit1, Samim Sahaji1, Anup Kumar Misra1
1Bose Institute, Division of Molecular Medicine, Block EN-80, Sector-V, Salt Lake, Kolkata, 700091, India.
Abstract:
Reduction of diselenides using a combination of hydrazine monohydrate and potassium hydroxide (KOH) followed by the treatment of the selenolate ions generated in situ with glycosyl halides under a one-pot, two-step phase transfer reaction condition resulted in the formation of beta-selenoglycosides in excellent yield. In addition, selenium linked disaccharide derivatives with beta-glycosidic linkages were also prepared by the reductive cleavage of diglycosyl diselenide derivatives in very good yield. The reaction condition is non-hazardous and high yielding for scaling up.
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