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Updated: Sep 26, 2025

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Hydrogen sulfide and metal interaction: the pathophysiological implications.
Devin Mantle1,2, Guangdong Yang3,4
1School of Natural Sciences, Laurentian University, 935 Ramsey Lake Road, Sudbury, ON, P3E 2C6, Canada.
Hydrogen sulfide (H₂S) is a signaling molecule that interacts with metals in the body. These interactions are crucial for its cellular functions, metabolism, and protection against metal toxicity.
Area of Science:
- Biochemistry
- Molecular Biology
- Physiology
Background:
- Hydrogen sulfide (H₂S) is recognized as a vital gaseous signaling molecule.
- Endogenous H₂S production occurs at low levels in mammals, influencing pathophysiological processes.
- H₂S interacts with essential metals like iron, copper, nickel, and zinc, impacting biological functions.
Purpose of the Study:
- To review the interactions between H₂S and metals.
- To explore metal-driven metabolism of H₂S.
- To discuss H₂S's protective role against metal toxicity and its detection using metals.
Main Methods:
- Literature review focusing on H₂S-metal interactions.
- Analysis of H₂S signaling pathways involving metals.
- Examination of H₂S detection methods utilizing metal interactions.
Main Results:
- H₂S-metal interactions are key to H₂S signal transduction and cellular metabolism.
- H₂S exhibits cytoprotective effects against metal toxicity.
- Advances in detecting H₂S have been driven by its interaction with metals.
Conclusions:
- Understanding H₂S-metal interactions is vital for elucidating H₂S cellular functions.
- These interactions offer potential for developing novel therapeutic strategies.
- Further research into H₂S-metal dynamics can advance biological and medical applications.
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