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Updated: Sep 26, 2025
08:34
Generation of Human Kidney Tubuloids from Tissue and Urine
Published on: April 16, 2021
5.1K
Growth control of the kidney
1The Rogosin Institute, New York, NY, United States.
Current Topics in Developmental Biology
|April 24, 2022
Summary
Kidney size is determined during development, but adult kidneys can grow. This review explores kidney growth mechanisms from development through adulthood, aiding stem cell therapies.
Area of Science:
- Nephrology
- Developmental Biology
- Physiology
Background:
- Kidney functional mass is crucial for adult health.
- Nephron endowment is established during development, with no known nephrogenesis post-development.
- Adult kidneys retain growth potential, demonstrated by compensatory hypertrophy after contralateral kidney loss.
Purpose of the Study:
- To review mechanisms controlling kidney size regulation.
- To examine nephron formation and cessation of nephrogenesis.
- To explore growth hormone-insulin-like growth factor signaling in kidney growth.
- To compare juvenile kidney growth with adult compensatory growth.
Main Methods:
- Review of existing literature on kidney development and growth.
- Analysis of genetic, cell biological, and hormonal controls.
- Examination of mouse models for kidney growth studies.
- Comparison of developmental, juvenile, and adult compensatory kidney growth.
Main Results:
- Nephrogenesis ceases post-development, fixing nephron number.
- Growth hormone and insulin-like growth factor pathways influence kidney growth pre- and postnatally.
- Compensatory kidney growth in adults shares mechanisms with juvenile growth.
Conclusions:
- Understanding kidney size regulation is key to addressing kidney disease.
- Mechanisms of kidney growth inform stem cell-based tissue generation.
- Further research into kidney growth set-points can advance regenerative medicine.
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