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Related Experiment Video

Updated: Sep 26, 2025

Simultaneous Isolation of Principal Central Nervous System-Resident Cell Types from Adult Autoimmune Encephalomyelitis Mice

Simultaneous Isolation of Principal Central Nervous System-Resident Cell Types from Adult Autoimmune Encephalomyelitis Mice

Published on: October 6, 2023

Single-cell multiomics in neuroinflammation.

Florian Ingelfinger¹, Eduardo Beltrán², Lisa A Gerdes²

¹Institute of Experimental Immunology, University of Zurich, Zurich, Switzerland; Department of Neurology, University Hospital Zurich, Zurich, Switzerland.

Current Opinion in Immunology

|April 24, 2022

Summary

This summary is machine-generated.

Neuroinflammation involves complex immune responses in the central nervous system (CNS). Single-cell multiomics reveals cellular heterogeneity, advancing our understanding of neuroinflammatory diseases and potential clinical applications.

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Last Updated: Sep 26, 2025

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Isolation of Region-specific Microglia from One Adult Mouse Brain Hemisphere for Deep Single-cell RNA Sequencing

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Published on: December 3, 2019

Area of Science:

Neuroscience
Immunology
Genomics

Background:

The central nervous system (CNS) is highly susceptible to inflammation.
Immune responses within the CNS must be strictly regulated for host protection.
Neuroinflammation is a complex process involving diverse cell types with dynamic changes upon CNS entry.

Purpose of the Study:

To provide an overview of technical advances in single-cell multiomics.
To highlight the impact of these technologies on understanding neuroinflammation.
To discuss applications in neuroinflammatory diseases and clinical settings.

Main Methods:

Review of single-cell multiomics technologies.
Analysis of data from studies on neuroinflammatory diseases.
Exploration of potential clinical translation of these tool sets.

Main Results:

Single-cell multiomics enables holistic resolution of cellular heterogeneity in the CNS.
These techniques have significantly reshaped the understanding of molecular and cellular processes in neuroinflammation.
Insights from various neuroinflammatory diseases have been elucidated.

Conclusions:

Single-cell multiomics are powerful tools for basic research in neuroinflammation.
These technologies offer promising avenues for understanding and potentially treating neuroinflammatory diseases.
Clinical applications of single-cell multiomics in neuroinflammation are expanding.