Circulating CTRP5 in rheumatoid arthritis: an exploratory biomarker study.

Area of Science:

• Immunology
• Endocrinology
• Rheumatology

Background:

• Rheumatoid arthritis (RA) is a cytokine-driven inflammatory disease.
• Adipokines, including CTRP5, are implicated in immune responses, but their roles in RA are debated.
• CTRP5 is a newly identified adipokine and adiponectin paralog.

Purpose of the Study:

• To investigate serum CTRP5 levels in RA patients.
• To compare CTRP5 levels between RA patients and healthy controls.
• To evaluate correlations between CTRP5 levels and clinical/laboratory parameters in RA.

Main Methods:

• Serum CTRP5 levels were quantified using ELISA.
• 46 RA patients and 22 healthy controls participated.
• Demographic, clinical, and laboratory features were assessed.

Main Results:

• Serum CTRP5 levels were significantly elevated in RA patients (p < 0.0001).
• CTRP5 levels correlated with triglyceride, ESR, CRP, and WBC counts.
• CTRP5 also correlated with interstitial lung disease (ILD) in RA patients.

Conclusions:

• Circulating CTRP5 levels are increased in RA patients.
• CTRP5 correlates with inflammation markers and RA comorbidities.
• CTRP5 may serve as a potential inflammatory biomarker for RA.