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Updated: Sep 26, 2025

A Data-Driven Approach to Quantifying Immune States in Sepsis
Published on: February 7, 2025
Investigation of a time-fractional COVID-19 mathematical model with singular kernel
Adnan1, Amir Ali1, Mati Ur Rahmamn2
1Department of Mathematics, University of Malakand, Dir(L), Khyber Pakhtunkhwa Pakistan.
This study explores fractional calculus models for coronavirus dynamics using Caputo derivatives. The findings show accurate approximations aligning well with numerical simulations and real-world data.
Area of Science:
- Mathematical Biology
- Fractional Calculus
- Epidemiology
Background:
- Mathematical models are crucial for understanding infectious disease dynamics.
- Fractional calculus offers a more nuanced approach to modeling complex phenomena like disease spread.
- Previous models often use integer-order derivatives, potentially missing finer dynamic details.
Purpose of the Study:
- To investigate the fractional dynamics of a coronavirus mathematical model using the Caputo derivative.
- To develop and validate approximate analytical solutions for the fractional model.
- To assess the existence, uniqueness, and stability of the model's solutions.
Main Methods:
- Application of Laplace-Adomian decomposition and Homotopy perturbation techniques for approximate series solutions.
- Utilizing the Banach fixed-point theorem to establish existence and uniqueness of solutions.
- Investigating Ulam-Hyers-type stability for the fractional coronavirus model.
Main Results:
- Approximate series solutions were successfully obtained for the fractional coronavirus model.
- The existence, uniqueness, and stability of the solutions were rigorously demonstrated.
- Comparisons between approximate solutions, numerical simulations, and real-world data showed strong agreement across various fractional orders.
Conclusions:
- Fractional calculus provides a powerful framework for modeling coronavirus dynamics with enhanced accuracy.
- The applied analytical techniques effectively approximate the complex behavior of the fractional model.
- The study validates the use of fractional-order models in epidemiological research, showing good agreement with integer-order models and real data.
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