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The direct and indirect effects of bioactive compounds against coronavirus

Merve Tomas1, Esra Capanoglu2, Akbar Bahrami3

  • 1Department of Food Engineering Faculty of Engineering and Natural Sciences Istanbul Sabahattin Zaim University Halkali Istanbul Turkey.

Food Frontiers
|April 25, 2022
PubMed

Insights

Natural bioactive compounds show promise in fighting COVID-19 by inhibiting viral entry and replication. These compounds also boost the immune system, offering a potential alternative to traditional therapies for coronavirus infections.

Area of Science:

  • Nutritional Immunology
  • Virology
  • Pharmacology

Background:

  • Emerging viral diseases like COVID-19 (Coronavirus Disease 2019) present a significant global health threat.
  • Rapid person-to-person transmission occurs via respiratory droplets, with no specific antiviral therapies currently available.
  • There is an urgent need for effective antiviral strategies to combat COVID-19.

Purpose of the Study:

  • To review existing literature on bioactive compounds with potential antiviral activity against COVID-19.
  • To explore mechanisms of action, including inhibition of viral entry, enzymes, and replication.
  • To assess the role of these compounds in immune system modulation.

Main Methods:

  • Literature review of scientific databases.
  • Analysis of studies on bioactive compounds such as polyphenols, glucosinolates, carotenoids, minerals, vitamins, oligosaccharides, bioactive peptides, essential oils, and probiotics.
  • Evaluation of reported antiviral mechanisms and immunomodulatory effects.

Main Results:

  • Various bioactive compounds demonstrate potential to inhibit coronavirus entry into host cells.
  • Certain compounds show efficacy in inhibiting key viral enzymes and replication processes.
  • Bioactive compounds can enhance the host immune system's response against the virus.

Conclusions:

  • Bioactive compounds found in functional foods offer a natural approach to combating COVID-19.
  • These compounds can serve as complementary strategies for immune support and viral inhibition.
  • Further research into functional foods and their bioactive constituents is warranted for infectious disease management.
Keywords:
COVID‐19antiviral activitybioactive compoundscoronavirusfunctional foodsimmune system

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