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Gut Microbiota Variations between Henoch-Schonlein Purpura and Henoch-Schonlein Purpura Nephritis

Fang Zhou1, Qimin Shao1, Lihong Jia1

  • 1Department of Rheumatoid Immune Nephrology, Hangzhou Children's Hospital, Hangzhou, 310014 Zhejiang, China.

Gastroenterology Research and Practice
|April 25, 2022
PubMed

Insights

Children with Henoch-Schonlein purpura (HSP) and HSP nephritis (HSPN) show altered gut microbiota compared to healthy children. This suggests potential for microbe-based therapies to improve outcomes for these conditions.

Area of Science:

  • Microbiology
  • Pediatrics
  • Gastroenterology

Background:

  • Gut microbiota differences between children with Henoch-Schonlein purpura (HSP) and HSP nephritis (HSPN) are not well understood in China.
  • HSP is an autoimmune disease causing inflammation in small blood vessels, often affecting the skin, joints, and kidneys.

Purpose of the Study:

  • To investigate and compare the gut microbiota composition in children diagnosed with HSP, HSPN, and healthy controls.
  • To identify potential microbial biomarkers associated with HSP and HSPN in pediatric populations.

Main Methods:

  • Recruited three groups of 25 children: HSP, HSPN, and healthy controls.
  • Analyzed fecal samples using 16S rRNA gene sequencing (V3-V4 region).
  • Compared gut microbial diversity and abundance between the groups.

Main Results:

  • Significant differences in gut microbial diversity were observed between the three groups (P = 0.0224).
  • Children with HSP exhibited lower Bifidobacterium abundance compared to healthy children and those with HSPN.
  • HSPN patients showed reduced Akkermansia and increased Alistipes abundance relative to HSP patients.

Conclusions:

  • The study indicates gut microbiota dysbiosis in children with HSP and HSPN.
  • Findings suggest that gut microbiota alterations may play a role in the pathogenesis of HSP and HSPN.
  • Results support the potential development of microbiome-targeted therapies for managing or preventing pediatric HSP and HSPN.
Abstract

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