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Updated: Sep 26, 2025

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Published on: August 6, 2021
Diagnosis of Retinal Diseases Based on Bayesian Optimization Deep Learning Network Using Optical Coherence Tomography
Malliga Subramanian1, M Sandeep Kumar2, V E Sathishkumar3
1Department of Computer Science Engineering, Kongu Engineering College, Perundurai, Erode 638060, Tamil Nadu, India.
This study uses deep learning models like DenseNet201 to detect seven retinal diseases from Optical Coherence Tomography (OCT) images with over 99% accuracy, enabling earlier and more precise diagnosis.
Area of Science:
- Ophthalmology
- Medical Imaging
- Artificial Intelligence
Background:
- Retinal abnormalities pose a significant public health risk, potentially leading to vision impairment and blindness.
- Early and accurate detection of retinal diseases is crucial for effective treatment and prevention of vision loss.
- Current diagnostic methods may not always provide the necessary precision or early detection.
Purpose of the Study:
- To investigate the efficacy of transfer learning using pretrained Convolutional Neural Network (CNN) models for detecting retinal diseases.
- To classify seven different retinal diseases using Optical Coherence Tomography (OCT) images.
- To compare the performance of various CNN models and identify the most accurate approach.
Main Methods:
- Utilized pretrained CNN models: VGG16, DenseNet201, InceptionV3, and Xception.
- Applied transfer learning to classify retinal diseases from a dataset of OCT images.
- Employed Bayesian optimization for hyperparameter tuning and image augmentation to enhance model generalization.
Main Results:
- DenseNet201 achieved an accuracy exceeding 99% in classifying retinal diseases from OCT images.
- The developed models demonstrated high accuracy in differentiating between healthy and diseased retinal images.
- A comparative analysis showed DenseNet201 outperformed other evaluated CNN models.
Conclusions:
- Transfer learning with CNNs, particularly DenseNet201, offers a highly accurate automated approach for retinal disease detection.
- This method provides a significant advancement over existing techniques, enabling classification of multiple retinal diseases.
- The findings support the potential of AI-driven tools for early and precise diagnosis of vision-threatening retinal conditions.
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