Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Migraine and drug absorption.

G N Volans

    Clinical Pharmacokinetics
    |July 1, 1978
    PubMed
    Summary
    This summary is machine-generated.

    Migraine attacks often involve gastrointestinal issues, slowing drug absorption like aspirin. Metoclopramide can improve absorption and recovery, suggesting its use before other migraine treatments.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Effects of food and exercise on the absorption of effervescent aspirin.

    British journal of clinical pharmacology·2012
    Same author

    The influence of thiethylperazine on the absorption of effervescent aspirin in migraine.

    British journal of clinical pharmacology·2012
    Same author

    Effects of drug overdose in television drama on presentations for self poisoning. Antifreeze poisonings give more insight into copycat behaviour.

    BMJ (Clinical research ed.)·1999
    Same author

    Apparent poisoning by wood preservatives: an attributional syndrome.

    Journal of psychosomatic research·1997
    Same author

    Optimum dose of digoxin.

    Lancet (London, England)·1997
    Same author

    Paracetamol overdose in pregnancy analysis of the outcomes of 300 cases referred to the Teratology Information Service.

    Reproductive toxicology (Elmsford, N.Y.)·1997
    Same journal

    Population Pharmacokinetic Modelling of Dolutegravir: A Narrative Review.

    Clinical pharmacokinetics·2026
    Same journal

    Partial Area Under the Curve: A Revelatory Story in Pharmacokinetics.

    Clinical pharmacokinetics·2026
    Same journal

    Informing Sampling Design for Lung Distribution Studies Using a Pulmonary Population Minimal PBPK Model.

    Clinical pharmacokinetics·2026
    Same journal

    Revisited Pharmacokinetic Profiles of Methylprednisolone in Plasma and Urine After Single and Multiple Oral Administrations: Relevance in Sports Drug Testing.

    Clinical pharmacokinetics·2026
    Same journal

    ALBI Grade is a Determinant of Lenvatinib Pharmacokinetics, Efficacy, and Toxicities in Japanese Patients with Hepatocellular Carcinoma.

    Clinical pharmacokinetics·2026
    Same journal

    Quantitative Pharmacology Justifying Ribociclib Dose in Early Breast Cancer.

    Clinical pharmacokinetics·2026
    See all related articles

    Area of Science:

    • Gastroenterology
    • Neurology
    • Clinical Pharmacology

    Background:

    • Migraine attacks frequently present with gastrointestinal symptoms.
    • These symptoms can significantly impact patient distress and daily functioning.
    • Gastrointestinal stasis and delayed gastric emptying are implicated in migraine pathophysiology.

    Purpose of the Study:

    • To investigate the effect of migraine on salicylate absorption from effervescent aspirin tablets.
    • To evaluate the efficacy of metoclopramide in improving aspirin absorption and migraine recovery.
    • To assess the role of gastrointestinal stasis in drug absorption during migraine.

    Main Methods:

    • Comparative study of aspirin absorption rates in migraine patients versus non-migraine volunteers and headache-free states.

    Related Experiment Videos

  • Administration of metoclopramide or thiethylperazine to assess their impact on aspirin absorption and migraine symptom resolution.
  • Assessment of gastric emptying rates in relation to drug absorption during migraine attacks.

    • Main Results:

    • Aspirin absorption rate was significantly reduced during migraine attacks compared to headache-free states.
    • Delayed aspirin absorption correlated with slower response times and increased need for additional treatment.
    • Metoclopramide improved aspirin absorption, accelerated recovery, and reduced the need for supplementary treatments, unlike thiethylperazine.

    Conclusions:

    • Migraine-associated gastrointestinal stasis impairs the absorption of orally administered drugs, including aspirin.
    • Metoclopramide can enhance gastric emptying, thereby improving the absorption and efficacy of medications like aspirin during migraine.
    • Rapidly absorbable drug formulations and metoclopramide should be considered for migraine management before exploring alternative administration routes.