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Renal Function Impact in the Prognostic Value of Galectin-3 in Acute Heart Failure

Pedro Caravaca Perez1,2, José R González-Juanatey1,3, Jorge Nuche1,4

  • 1CIBER de Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain.

Frontiers in Cardiovascular Medicine
|April 25, 2022
PubMed

Insights

Galectin-3 (Gal-3) predicts mortality in acute heart failure (AHF) patients, but its prognostic value is significant only in those with renal dysfunction. Renal function impacts Gal-3 interpretation in AHF.

Area of Science:

  • Cardiology
  • Nephrology
  • Biomarker Research

Background:

  • Galectin-3 (Gal-3) is an inflammatory marker linked to heart failure (HF) progression.
  • The interplay between Gal-3 and renal function in acute HF (AHF) requires further investigation.

Purpose of the Study:

  • To assess the prognostic relationship between renal function and Gal-3 levels in patients hospitalized for AHF.
  • To determine if renal function modifies the predictive value of Gal-3 for mortality.

Main Methods:

  • An observational, prospective, multicenter registry of 1,201 AHF patients.
  • Patients were stratified by estimated glomerular filtration rate (eGFR) into preserved (≥60 mL/min/1.73 m²) and impaired (<60 mL/min/1.73 m²) renal function groups.
  • Cox regression analysis evaluated Gal-3 association with 12-month mortality, adjusting for eGFR and other variables.

Main Results:

  • Gal-3 levels negatively correlated with eGFR (rho = -0.51, p < 0.001).
  • Elevated Gal-3 was associated with higher 12-month mortality in multivariate analysis (HR = 1.010, p = 0.038).
  • Prognostic value of Gal-3 was significant in patients with renal dysfunction (HR = 1.010, p = 0.033) but not in those with preserved renal function (HR = 0.990, p = 0.472).

Conclusions:

  • Galectin-3 is a marker of increased mortality in AHF patients with renal dysfunction.
  • Renal function significantly influences the prognostic utility of Gal-3 in AHF.
  • eGFR adjustment is crucial for accurate interpretation of Gal-3 levels in AHF.
Abstract

Keywords:
acute heart failure (AHF)cardiorenal syndrome (CRS)galectin-3 (Gal-3)prognosisrenal function

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