Related Experiment Video

Updated: Sep 26, 2025

Murine Kidney Transplant Technique
08:58

Murine Kidney Transplant Technique

Published on: October 20, 2015

16.4K

Pearls and Pitfalls in Pediatric Kidney Transplantation After 5 Decades

Loes Oomen1, Charlotte Bootsma-Robroeks2,3, Elisabeth Cornelissen2

  • 1Division of Pediatric Urology, Department of Urology, Radboudumc Amalia Children's Hospital, Nijmegen, Netherlands.

Frontiers in Pediatrics
|April 25, 2022
PubMed

Insights

Pediatric kidney transplantation has advanced significantly since 1959, with pre-emptive transplants improving graft survival. Future research should focus on immunosuppression, adherence, donor selection, surgical techniques, and urinary tract function.

Area of Science:

  • Nephrology
  • Pediatric Surgery
  • Immunology

Background:

  • Over 1,300 pediatric kidney transplantations occur annually worldwide.
  • Significant advancements in pediatric kidney transplantation since 1959.
  • Increased prevalence of pre-emptive transplantation and living donor grafts has improved outcomes.

Purpose of the Study:

  • To summarize the evolution of pediatric kidney transplantation.
  • To identify current challenges and future research directions.
  • To compare existing literature with single-center data (1968-2020).

Main Methods:

  • Literature review of pediatric kidney transplantation.
  • Analysis of 411 single-center pediatric kidney transplantations (1968-2020).
  • Comparative analysis to identify discrepancies and future challenges.

Main Results:

  • Improved graft survival due to advancements in care.
  • Identification of key areas for future research and development.
  • Established a historical perspective on pediatric kidney transplantation outcomes.

Conclusions:

  • Future pediatric kidney transplantation care requires innovation in immunosuppressive medications and improved medication adherence.
  • Careful donor selection based on donor and recipient characteristics is crucial.
  • Addressing lower urinary tract dysfunction and voiding behavior is essential for long-term patient success.

Keywords:
donor selectiongraft survivalimmunosuppressionlower urinary tract dysfunctionpediatric kidney transplantationpediatric nephrologypediatric urology

More Related Videos

Heterotopic Renal Autotransplantation in a Porcine Model: A Step-by-Step Protocol11:47

Heterotopic Renal Autotransplantation in a Porcine Model: A Step-by-Step Protocol

Published on: February 21, 2016

12.0K
Robot-Assisted Kidney Transplantation07:30

Robot-Assisted Kidney Transplantation

Published on: July 19, 2021

3.8K

Related Concept Videos

Kidney Transplant I: Introduction01:28

Kidney Transplant I: Introduction

A kidney transplant is a surgical approach that involves replacing a non-functioning kidney with a healthy one from a donor. This procedure is often a treatment option for end-stage renal disease (ESRD) patients. The method requires careful recipient selection, including evaluating various medical and psychosocial factors. These criteria vary between transplant centers but generally include assessments of the patient's overall health, adherence to medical recommendations, and lifestyle...
66
Kidney Transplant II: Surgical Procedure01:26

Kidney Transplant II: Surgical Procedure

Preoperative ManagementThe primary goals of preoperative management in kidney transplantation are to optimize the patient’s metabolic state and prepare them for surgery through diet adjustments, necessary dialysis, and tailored medical treatment. This phase also involves comprehensive infection screening and patient education about the surgical procedure and postoperative care to improve outcomes and adherence.Medical ManagementA comprehensive evaluation is required for both the living...
82
Kidney Transplant III: Nursing Management01:16

Kidney Transplant III: Nursing Management

Postoperative Nursing Management for Kidney Transplant PatientsPostoperative nursing management care includes monitoring the surgical site, encouraging early movement, and promoting lung health through breathing exercises. Nurses also administer prescribed medications like H2-blockers, such as famotidine, or proton pump inhibitors, like omeprazole, to help prevent gastrointestinal ulcers and bleeding. Fungal infections in the mouth and bladder can result from immunosuppressive and antibiotic...
89
Acute Kidney Injury I: Introduction01:22

Acute Kidney Injury I: Introduction

Introduction:Acute Kidney Injury (AKI) describes a swift decrease in kidney function occurring over hours to days, characterized by the kidneys' failure to remove waste products from the bloodstream. This leads to dangerous complications like metabolic acidosis, fluid overload, and electrolyte imbalances, such as hyperkalemia, which can cause life-threatening arrhythmias. AKI is common in both hospital and outpatient settings, often triggered by dehydration, sepsis, or exposure to nephrotoxic...
100
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...
67
Tissue Transplantation01:24

Tissue Transplantation

Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
The Biology of Tissue Transplantation
The biology of tissue transplantation hinges on the Major Histocompatibility Complex (MHC) molecules. These molecules...
537