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Clinical and Microbial Etiology Characteristics in Pediatric Urinary Tract Infection

Jiandong Lu1, Xiaozhu Liu2, Yi Wei1

  • 1Department of Urology, National Clinical Research Center for Child Health and Disorders, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics Chongqing, Children's Hospital of Chongqing Medical University, Chongqing, China.

Frontiers in Pediatrics
|April 25, 2022
PubMed

Insights

Pediatric urinary tract infections (UTIs) linked to urological malformations present with atypical microbes and higher recurrence rates. Early diagnosis with imaging and urine culture is crucial for effective management of childhood UTIs.

Area of Science:

  • Pediatric Urology
  • Infectious Diseases
  • Medical Microbiology

Background:

  • Urinary tract infections (UTIs) are common in children and are closely associated with urological malformations.
  • The impact of urological malformations on the clinical presentation of pediatric UTIs requires further elucidation.

Purpose of the Study:

  • To characterize the clinical features and microbial etiology of UTIs in children.
  • To investigate the influence of urological malformations on UTI presentation and outcomes in pediatric patients.

Main Methods:

  • Retrospective review of 741 pediatric UTI cases from 2015-2020.
  • Propensity score matching (PSM) to compare patients with and without urological malformations.

Main Results:

  • Escherichia coli was the predominant pathogen (40.5%).
  • Urological malformations were present in 16.5% of patients.
  • Patients with malformations had a higher proportion of atypical UTI microorganisms (P=0.048), longer IV antibiotic treatment, increased costs, and higher recurrence rates (23.8% vs. 10.7%, P<0.001).

Conclusions:

  • Children with urological malformations are more prone to developing UTIs caused by atypical microorganisms.
  • Recommended diagnostic approaches include imaging and urine culture for pediatric UTIs, especially in cases with suspected malformations.
Abstract

Keywords:
childrencongenital anomalies of the kidney and urinary tract (CAKUT)pediatricurinary tract infectionurological abnormalities

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