Related Experiment Video

Updated: Sep 26, 2025

Histological Quantification of Chronic Myocardial Infarct in Rats
09:45

Histological Quantification of Chronic Myocardial Infarct in Rats

Published on: December 11, 2016

14.8K

Prognostic Value of a Novel Parameter in Patients with Infective Endocarditis

Ying Chen1,2, Jingping Liu1,2, Tengfei Qiao3

  • 1Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China.

Biomed Research International
|April 25, 2022
PubMed

Insights

The lactate dehydrogenase (LDH)/lymphocyte ratio (L-LWR) effectively predicts in-hospital mortality in infective endocarditis (IE) patients. This easily applicable marker demonstrates good performance and reliability for assessing prognosis in IE.

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Medical Diagnostics

Background:

  • Infective endocarditis (IE) is associated with high mortality and poor prognosis.
  • Predictive markers for in-hospital mortality in IE patients are crucial for clinical management.

Purpose of the Study:

  • To evaluate the predictive value of the lactate dehydrogenase (LDH)/lymphocyte ratio (L-LWR) for in-hospital mortality in IE patients.
  • To compare the efficacy of L-LWR with the LDH/lymphocyte percentage (L-LWR) in predicting outcomes.

Main Methods:

  • Retrospective analysis of medical records from 147 IE patients (January 2017 - December 2019).
  • Selection of admission indexes for statistical analysis.
  • Comparison of L-LWR and LDH/lymphocyte levels between patients with and without adverse events.

Main Results:

  • IE patients without adverse events showed significantly higher LDH/lymphocyte levels and lower L-LWR.
  • L-LWR remained an independent predictor of mortality after adjustments (OR: 4.558, P=0.014).
  • L-LWR demonstrated high predictive accuracy (AUC: 0.780) with good sensitivity (81.89%) and specificity (65.00%) at a cutoff of 34.

Conclusions:

  • L-LWR is a reliable, cost-effective, and easily applicable prognostic marker for in-hospital mortality in IE.
  • The L-LWR shows good performance and independence in predicting outcomes for patients with infective endocarditis.
Abstract

More Related Videos

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

5.4K
Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia07:25

Predicting Amputation using Local Circulating Mononuclear Progenitor Cells in Angioplasty-treated Patients with Critical Limb Ischemia

Published on: September 22, 2020

3.5K

Related Concept Videos

Endocarditis IV: Nursing Management01:29

Endocarditis IV: Nursing Management

Infective endocarditis (IE) is a chronic infection of the heart's endocardium, primarily affecting the heart valves. A detailed nursing assessment for a patient with IE involves collecting subjective and objective data to ensure an accurate diagnosis and timely intervention.Subjective DataThe nurse gathers information about the patient's symptoms and complaints during the subjective assessment. Patients with infective endocarditis often report non-specific symptoms that can mimic other...
53
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
33
Endocarditis III: Medical Management01:18

Endocarditis III: Medical Management

Infective endocarditis management involves a multifaceted approach encompassing infection prevention, lifestyle modifications, pharmacological therapy, and surgical management.Infection Prevention:Hand Hygiene: Thorough handwashing is crucial to prevent the spread of infection. Hand hygiene should be performed regularly, especially before and after using the restroom.Oral Hygiene: Good oral hygiene is essential. It includes brushing teeth immediately after waking up and before bed, flossing...
31
Endocarditis I: Introduction01:25

Endocarditis I: Introduction

Introduction:Endocarditis is the infection of the endocardium, the inner lining of the heart and its valves. When the heart muscle is involved, the condition is termed myocarditis, while an infection of the outer lining is called pericarditis. Infective endocarditis (IE) primarily affects the endocardium, where pathogens adhere to the valves or lining, forming vegetation that can lead to severe complications. Infective endocarditis occurs when microorganisms, usually bacteria from other body...
45
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
31
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
34