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Related Experiment Video

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Ectopic Laryngeal Ossification after Bone Morphogenetic Protein-2.

Kirsten Wong1, Edward Damrose2, Jennifer Long1,3,4

  • 1David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA.

Surgeries
|April 25, 2022
PubMed
Summary
This summary is machine-generated.

Recombinant human bone morphogenetic protein-2 (rhBMP-2) may cause ectopic bone formation in the head and neck. This report details two cases of abnormal bone growth, urging caution with rhBMP-2 applications.

Keywords:
anterior spine surgerybenign vocal fold lesionshead and neck surgerylarynxossificationswallow/dysphagia

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Area of Science:

  • Otolaryngology
  • Orthopedic Surgery
  • Biomaterials Science

Background:

  • Recombinant human bone morphogenetic protein-2 (rhBMP-2) is a potent osteoinductive agent used in various surgical applications.
  • Previous studies have documented ectopic bone formation and adverse events, such as swelling and dysphagia, following rhBMP-2 use, particularly in cervical spine surgery.

Purpose of the Study:

  • To report two distinct cases of ectopic bone formation in the head and neck region after rhBMP-2 treatment.
  • To highlight the potential risks associated with rhBMP-2, emphasizing the need for careful dosing and increased clinical awareness.

Main Methods:

  • Case report methodology involving detailed review of surgical pathology.
  • Utilized laryngoscopy and CT imaging for diagnostic assessment.
  • Compiled comprehensive patient medical histories.

Main Results:

  • Case 1: A 67-year-old male developed osseous metaplasia in the vocal fold post-mandibular dental implants with rhBMP-2.
  • Case 2: A 73-year-old male experienced severe laryngeal bony overgrowth and anterior cervical spine (ACS) fusion after multiple anterior cervical discectomies and fusions with rhBMP-2.
  • Both cases presented unusual patterns of abnormal bone growth in soft tissue areas of the head and neck.

Conclusions:

  • The presented cases strongly suggest a link between rhBMP-2 application and ectopic bone formation in the head and neck.
  • Clinicians should be aware of these potential adverse effects, especially concerning the use of rhBMP-2 in cervical spine and dental procedures.
  • Caution in rhBMP-2 dosing is strongly recommended to mitigate risks of abnormal bone growth.