Related Experiment Video

Updated: Sep 25, 2025

Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders
06:39

Intracoronary Acetylcholine Provocation Testing for Assessment of Coronary Vasomotor Disorders

Published on: August 18, 2016

16.1K

Association of anti-neutrophil cytoplasmic antibody-associated vasculitis and cardiovascular events: a

David Massicotte-Azarniouch1, William Petrcich2, Michael Walsh3

  • 1Department of Medicine, University of Ottawa, Ontario, Canada.

Clinical Kidney Journal
|April 25, 2022
PubMed

Insights

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) increases the risk of stroke, atrial fibrillation, and congestive heart failure, especially soon after diagnosis. This cardiovascular risk highlights the need for vigilant monitoring in AAV patients.

Area of Science:

  • Nephrology
  • Rheumatology
  • Cardiology

Background:

  • Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is linked to increased cardiovascular (CV) disease risk.
  • The specific types of CV diseases affected by AAV remain unclear.

Purpose of the Study:

  • To investigate the association between AAV and adverse CV outcomes.
  • To compare CV event rates in AAV patients versus a non-AAV population.

Main Methods:

  • A population-based, retrospective cohort study in Ontario, Canada (2007-2017).
  • Inclusion of 1520 adults with new AAV diagnosis and 5834 matched controls.
  • Outcomes included major adverse CV events (MACE), stroke, myocardial infarction (MI), CV death, atrial fibrillation (AF), and congestive heart failure (CHF).

Main Results:

  • AAV patients showed higher risks of stroke (sHR 1.49), AF (sHR 1.51), and CHF (sHR 1.41) compared to controls.
  • Elevated risks for AF and CHF were particularly pronounced in the 90-day and 365-day periods post-diagnosis.
  • No significant association was found between AAV and MACE, MI, or CV death.

Conclusions:

  • AAV is associated with a significantly increased risk of specific cardiovascular events, including stroke, AF, and CHF.
  • The heightened risk for these CV events is most prominent in the early period following AAV diagnosis.
Abstract

Keywords:
ANCA-associated vasculitisatrial fibrillationcardiovascular eventscongestive heart failure

More Related Videos

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research08:42

Ultrasound Assessment of Endothelial-Dependent Flow-Mediated Vasodilation of the Brachial Artery in Clinical Research

Published on: October 22, 2014

27.5K
Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis07:51

Hydra, a Computer-Based Platform for Aiding Clinicians in Cardiovascular Analysis and Diagnosis

Published on: September 26, 2018

7.7K

Related Concept Videos

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
83
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
44
Psychoneuroimmunology: Cardiovascular Disease01:27

Psychoneuroimmunology: Cardiovascular Disease

Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
A key area of focus in PNI is the relationship between stress and coronary...
85
Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers01:19

Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers

Cardiac biomarkers are critical in diagnosing, prognosing, and managing cardiovascular diseases. Routine measurement of specific biomarkers such as B-type natriuretic peptide (BNP), C-reactive protein (CRP), and homocysteine (Hcy) is common practice in clinical settings to evaluate heart function and predict cardiovascular events.
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
237
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
58
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
57