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Related Concept Videos

Alzheimer's Disease: Treatment01:22

Alzheimer's Disease: Treatment

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Alzheimer's Disease (AD), a neurodegenerative disorder, is pathologically identified by amyloid plaques and neurofibrillary tangles composed of tau protein. AD pharmacotherapy aims to manage cognitive symptoms, delay disease progression, and treat behavioral symptoms. The treatment is primarily symptomatic and palliative, with no definitive disease-modifying therapy available. Cholinesterase inhibitors, including donepezil (Aricept), rivastigmine (Exelon), and galantamine (Razadyne), are...
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Somatic to iPS Cell Reprogramming01:29

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Reprogramming alters the gene expression in somatic cells, transforming them into induced pluripotent stem (iPS) cells over several generations. Scientists can reprogram cells by introducing genes for four transcription factors—Oct4, Sox2, Klf4, and c-Myc (OSKM) by viral or non-viral methods. These factors are also known as Yamanaka factors after Shinya Yamanaka, who first generated iPS cells using mouse skin cells. Yamanaka was awarded the Nobel Prize in Physiology or Medicine in 2012...
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Introduction to Nuclear Reprogramming01:14

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Nuclear reprogramming is the process of switching gene expression of one cell type to that of another cell type, usually from a differentiated cell state to an undifferentiated cell state. Differentiation occurs during processes such as development and morphogenesis, tissue regeneration, and malignancy. Cells can also be artificially induced to reprogram their gene expression by techniques such as nuclear transfer, induced pluripotency, and cell fusion. Such techniques have many applications in...
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Nuclear reprogramming is a process of transforming one cell type into an unrelated cell type by epigenetic changes that alter the cell’s original gene expression pattern. Such epigenetic changes force cells to express a different set of genes, which play a significant role in inducing transformation into other cell types. Nuclear reprogramming offers applications in reproductive cloning for livestock propagation and regenerative medicine — developing patient-specific cells for...
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Alzheimer's Disease: Overview01:26

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
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Related Experiment Video

Updated: Sep 25, 2025

In vitro Modeling for Neurological Diseases using Direct Conversion from Fibroblasts to Neuronal Progenitor Cells and Differentiation into Astrocytes
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Cellular Reprogramming and Its Potential Application in Alzheimer's Disease.

Chao Zhou1,2, Wanyan Ni1,2, Taiyang Zhu1,2

  • 1Institute of Neurological Diseases, Xuzhou Medical University, Xuzhou, China.

Frontiers in Neuroscience
|April 25, 2022
PubMed
Summary

Cellular reprogramming offers a promising new avenue for Alzheimer's disease (AD) therapy by converting non-neuronal cells into functional neurons. This approach addresses the challenge of restoring neural networks in AD patients.

Keywords:
Alzheimer’s diseasecellular reprogrammingiPSCsneurological functionneuroregeneration

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Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases
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Chemogenetic Regulation in Reprogrammed Stem Cell-derived Precursor Cells in Treating Neurodegenerative Diseases

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Area of Science:

  • Neuroscience
  • Regenerative Medicine
  • Cell Biology

Background:

  • Alzheimer's disease (AD) is the leading cause of age-related dementia and remains incurable.
  • Complex mechanisms including amyloid-beta plaques, tau tangles, and neuronal death contribute to AD pathogenesis.
  • Restoring functional neurons and myelin is a key therapeutic challenge in AD.

Purpose of the Study:

  • To review the characteristics of Alzheimer's disease.
  • To explore the potential of cellular reprogramming as a therapeutic strategy for AD.
  • To summarize current research on cellular reprogramming applications in AD.

Main Methods:

  • Review of existing literature on Alzheimer's disease.
  • Analysis of induced pluripotent stem cell and direct cell reprogramming technologies.
  • Examination of studies applying cellular reprogramming to AD models.

Main Results:

  • Cellular reprogramming can induce non-neuronal cells into functional neurons in vitro and in vivo.
  • Induced neurons demonstrate integration into neural networks.
  • This technology presents a novel therapeutic approach for AD.

Conclusions:

  • Cellular reprogramming holds significant therapeutic potential for Alzheimer's disease.
  • Further research is needed to address existing challenges and optimize this approach.
  • This strategy offers a new direction for AD treatment development.