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Acute Promyelocytic Leukemia in a Patient With Chronic Continuous Type of Crohn's Disease

Shiori Kinoshita1, Satoshi Tanida2, Akimi Kawai3

  • 1Department of Hematology, Toyokawa City Hospital, Toyokawa City, Aichi Prefecture, Japan.

Journal of Clinical Medicine Research
|April 25, 2022
PubMed

Insights

Chronic inflammation from Crohn's disease may cause mutations in hematopoietic stem cells (HSCs), potentially leading to acute promyelocytic leukemia (APL). This rare APL manifestation highlights the need for vigilance in Crohn's disease patients.

Area of Science:

  • Hematology
  • Oncology
  • Gastroenterology

Background:

  • Chronic inflammation is a known risk factor for leukemogenesis.
  • Crohn's disease is a chronic inflammatory condition affecting the gastrointestinal tract.

Observation:

  • A patient with long-standing Crohn's disease developed acute promyelocytic leukemia (APL).
  • The patient was diagnosed with Crohn's disease at age 28 and APL at age 51, having received biologic therapy but not azathioprine.

Findings:

  • The development of APL in this case suggests a potential link between chronic inflammation from Crohn's disease and leukemic transformation.
  • Genomic instability in hematopoietic stem cells (HSCs) due to chronic inflammation may predispose individuals to APL.

Implications:

  • This case underscores the importance of monitoring Crohn's disease patients for rare hematological malignancies like APL.
  • Further research is warranted to elucidate the mechanisms linking chronic inflammation in Crohn's disease to HSC genomic instability and leukemogenesis.

Keywords:
Acute promyelocytic leukemiaChronic inflammationCrohn’s diseaseHematopoietic stem cellInflammatory bowel diseaseMyeloid neoplasm

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