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Risk Factors for Coronary Heart Disease Among Lebanese Women: A Case-Control Study
Fatima Ghaddar1, Rouba K Zeidan2,3,4,5, Pascale Salameh4,6,7,8
1Doctoral School of Biology Health and Biotechnologies, Toulouse University, Toulouse, France.
Insights
Coronary heart disease risk factors in Lebanese women over forty were identified. Post-menopausal women showed higher risks from dyslipidemia, hypertension, and smoking, necessitating targeted prevention strategies.
Area of Science:
- Cardiology
- Public Health
- Women's Health
Background:
- Coronary heart disease (CHD) presents unique risk factors in women.
- Understanding these specific risks is crucial for effective prevention.
Purpose of the Study:
- To assess the risk factors for coronary heart disease (CHD) in Lebanese women over forty.
- To identify differences in risk factors between pre- and post-menopausal women.
Main Methods:
- A case-control study involving 1500 women (300 cases, 1200 controls) in Beirut and Mount-Lebanon.
- Data collected via interviews and hospital records, analyzed using binary logistic regression.
- Participants stratified into pre- and post-menopausal groups.
Main Results:
- In post-menopausal women, CHD was associated with dyslipidemia, hypertension, family history of CHD, smoking, and joint pain.
- Protective factors included living in Mount Lebanon, moderate income, Mediterranean diet, and physical activity.
- In pre-menopausal women, dyslipidemia, hypertension, and family history of dyslipidemia/CHD were significant risk factors.
Conclusions:
- CHD risk factors in women, especially post-menopause, require specific attention.
- Highlights the need for tailored CHD prevention strategies for women.
- Emphasizes the importance of addressing modifiable risk factors like diet and physical activity.
Purpose:
Women are increasingly concerned by coronary heart disease (CHD), with peculiarities of their own, particularly concerning risk factors. The aim of the study was to assess the risk factors for CHD in Lebanese women over forty.
Patients And Methods:
A case-control study was carried out in 6 hospitals in Beirut and Mount-Lebanon, from December 2018 to December 2019 including 1500 patients (1200 controls and 300 cases). Women were stratified into pre- and post-menopausal groups. Personal and medical data were collected from hospital records and during an interview where validated questionnaires were used. Binary logistic regressions were performed to investigate potential predictors of CHD in the 2 groups.
Results:
In post-menopausal women, dyslipidemia (adjusted odds ratio [aOR], 3.018; 95% confidence interval, 2.102-4.332), hypertension (aOR: 2.449, [1.386-4.327]), a family history of CHD (aOR: 2.724, [1.949-3.808]), cigarette smoking (aOR: 2.317, [1.574-3.410]) and common non-rheumatic joint pain (aOR: 1.457, [1.053-2.016]) were strongly associated with CHD. Conversely, living in Mount Lebanon seemed protective, compared to Beirut (aOR: 0.589, [0.406-0.854]), as well as having a moderate monthly income (aOR: 0.450, [0.220-0.923]), adhering to a Mediterranean diet (aOR: 0.965, [0.936-0.994]), and practicing physical activity [PA] (aOR: 0.396, [0.206-0.759] and 0.725, [0.529-0.992], respectively for high and moderate vs low PA). In pre-menopausal women, dyslipidemia (aOR: 6.938, [1.835-26.224]), hypertension (aOR: 6.195, [1.318-29.119]), family histories of dyslipidemia (aOR: 6.143, [1.560-24.191]) and CHD (aOR: 4.739, [1.336-16.805]) reached statistical significance.
Conclusion:
The identification of factors associated with CHD in women, some of which are frequent and trivialized in post-menopause, underlines the need to put in place specific and dedicated CHD prevention strategies in women.
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