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Longitudinal changes in an autonomously functioning thyroid nodule with coexisting follicular thyroid carcinoma over
Taisuke Uchida1, Hideki Yamaguchi1, Takayuki Kawabata2
1Division of Hematology, Diabetes, and Endocrinology, Department of Internal Medicine, Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.
Oxford Medical Case Reports
|April 25, 2022
Summary
An autonomously functioning thyroid nodule (AFTN) that grew over time was diagnosed alongside follicular thyroid carcinoma (FTC). The nodule
Area of Science:
- Endocrinology
- Oncology
- Pathology
Background:
- Autonomously functioning thyroid nodules (AFTNs) can present diagnostic challenges.
- Coexistence of AFTN and thyroid malignancy requires careful evaluation.
- Hashimoto's thyroiditis can complicate thyroid nodule assessment.
Observation:
- A 33-year-old female presented with a growing left thyroid nodule detected initially at age 21.
- The nodule increased from 13 mm to 33 mm, associated with subclinical and later overt hyperthyroidism.
- Fine needle aspiration cytology suggested follicular neoplasm with Hashimoto's thyroiditis.
Findings:
- Thyroid scintigraphy confirmed an AFTN with elevated uptake in the left lobe.
- Pathological diagnosis post-thyroidectomy revealed follicular thyroid carcinoma (FTC) with capsular invasion.
- Longitudinal growth of the AFTN was a key indicator for suspected malignancy.
Implications:
- Rapid or continuous growth of an AFTN may warrant investigation for coexisting thyroid cancer.
- Surgical management is crucial for definitive diagnosis and treatment of FTC.
- This case highlights the importance of monitoring nodule size and clinical presentation in AFTN management.
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