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Updated: Sep 25, 2025

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Published on: August 13, 2019
Vasospasm-induced ST-segment elevation myocardial infarction in a premenopausal woman with endothelial dysfunction
Bonpei Takase1, Yukie Kobayashi2, Natsuko Sasaki2
1Department of Intensive Care Medicine, National Defense Medical College, Tokorozawa city, Saitama, Japan.
Abstract:
ST-segment elevation myocardial infarction (STEMI) can be caused by coronary artery vasospasm (VSA) due to endothelial dysfunction. However, the clinical role of endothelial function tests in VSA-induced STEMI is not fully understood. We present the case of a 43-year-old woman with atypical chest pain and no coronary risk factors. STEMI caused by VSA was diagnosed. Flow-mediated vasodilatation (FMD) and EndPAT tests were performed; the FMD and reactive hyperaemia index were 3.8% and 1.23, respectively. Endothelial dysfunction is the putative cause of STEMI. FMD and EndPAT tests might be useful for predicting adverse outcomes in young premenopausal women with VSA.
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