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Echocardiographic Parameters and Outcomes in Methamphetamine-Associated Heart Failure: A Propensity Score-Weighted
Jakrin Kewcharoen1, Andrew K Chang1, Purvi Parwani1
1Department of Medicine, Division of Cardiology, Loma Linda University Medical Center, Loma Linda, CA, USA.
Cardiology Research
|April 25, 2022
Summary
Methamphetamine-associated heart failure (MethHF) patients had similar outcomes to non-MethHF patients after adjustments. Tricuspid regurgitation (TR) on echocardiogram predicted outcomes in MethHF patients.
Area of Science:
- Cardiology
- Toxicology
- Public Health
Background:
- Methamphetamines are a significant cause of systolic heart failure (HF).
- Limited data exist on prognosis for decompensated HF hospitalizations linked to methamphetamine use.
- Understanding outcomes in methamphetamine-associated heart failure (MethHF) is crucial.
Purpose of the Study:
- To evaluate patient characteristics and outcomes of decompensated HF hospitalizations in methamphetamine users.
- To identify transthoracic echocardiogram (TTE) parameters predicting outcomes in MethHF.
- To compare outcomes between MethHF and non-MethHF groups.
Main Methods:
- Retrospective cohort study (2013-2018) at Loma Linda Medical Center.
- Defined MethHF by positive urine drug screen for methamphetamines.
- Analyzed 30-day composite outcomes, 365-day mortality, and length of stay using propensity score weighting.
Main Results:
- 1,655 patients included: 101 MethHF, 1,554 non-MethHF.
- MethHF patients were younger, more male, had fewer comorbidities, lower LVEF, and more RV dysfunction.
- No significant differences in LOS, 30-day composite outcome, or 365-day mortality between groups after weighting.
Conclusions:
- MethHF patients admitted for decompensated HF had similar outcomes to non-MethHF patients post-adjustment.
- Tricuspid regurgitation (TR) was the sole TTE predictor for 30-day composite outcomes and 365-day mortality in the MethHF group.
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