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Epilepsy and Seizures: Overview

Epilepsy and Seizures: Overview

Epilepsy is a chronic neurological disease marked by recurrent, unpredictable seizures. These seizures are caused by abnormal electrical discharges in the brain, leading to behavior, sensation, or consciousness alterations. They can also cause transient impairment of awareness, interfering with daily activities.
Various factors can trigger epilepsy, including genetic factors, brain damage, metabolic causes, and unknown etiology. Diagnosis of epilepsy involves electroencephalography (EEG), which...

Seizures: Classification

Seizures: Classification

Epilepsy is primarily characterized by unpredictable seizures, either provoked by an identifiable factor, such as injury or illness, or unprovoked, occurring spontaneously without apparent cause.
Seizures are typically classified into two main categories: focal and generalized seizures.
Focal Seizures
Focal seizures originate from specific regions of the brain. These seizures are further sub-classified into two types:

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Related Experiment Video

Updated: Sep 25, 2025

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Network Analysis of Foramen Ovale Electrode Recordings in Drug-resistant Temporal Lobe Epilepsy Patients

Published on: December 18, 2016

DREADDs in Epilepsy Research: Network-Based Review.

John-Sebastian Mueller¹, Fabio Cesar Tescarollo¹, Hai Sun¹

¹Department of Neurosurgery, Robert Wood Johnson Medical School, New Brunswick, NJ, United States.

Frontiers in Molecular Neuroscience

|April 25, 2022

Summary

This summary is machine-generated.

Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) offer precise control over neuronal activity, advancing epilepsy research. This review highlights DREADD applications in understanding epilepsy mechanisms and potential therapeutic uses.

Keywords:

DREADD = designer receptor exclusively activated by designer drugs chemogenetic epilepsy epileptogenesis ictogenesis pharmaco-genetic seizure

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Generation and On-Demand Initiation of Acute Ictal Activity in Rodent and Human Tissue

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Published on: January 19, 2019

Area of Science:

Neuroscience
Epileptology
Pharmacology

Background:

Epilepsy is characterized by altered brain rhythms due to neuronal overexcitation or inhibition.
Chemogenetics provides tools for targeted neuronal manipulation.
Designer Receptors Exclusively Activated by Designer Drugs (DREADDs) are key chemogenetic tools.

Purpose of the Study:

To review the application of DREADDs in epilepsy research.
To summarize current findings on DREADDs in experimental epilepsy.
To explore the therapeutic potential of DREADDs for epilepsy treatment.

Main Methods:

Review of existing literature utilizing DREADDs in epilepsy models.
Analysis of studies investigating neuronal excitation and inhibition using DREADDs.
Exploration of DREADD-based therapeutic strategies.

Main Results:

DREADDs enable precise, on-demand control of neuronal activity with high specificity.
DREADDs have been instrumental in elucidating cellular and network mechanisms of epilepsy.
Significant insights into epilepsy pathophysiology have been gained through DREADD applications.

Conclusions:

DREADDs are powerful tools for advancing epilepsy research.
Further research may lead to innovative DREADD-based therapeutic interventions for epilepsy.
DREADDs hold promise for future epilepsy treatment strategies.