Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Variability: Analysis01:11

Variability: Analysis

199
Measures of variability are statistical metrics that reveal the dispersion pattern within a dataset. They are pivotal in biostatistics, providing insights into the heterogeneity within health and biological data. Variability signifies the degree to which data points diverge from one another, helping researchers understand the potential range of values and associated uncertainty within the data.
The range is a simple measure of variability, indicating the difference between the highest and...
199
Outliers and Influential Points01:08

Outliers and Influential Points

4.4K
An outlier is an observation of data that does not fit the rest of the data. It is sometimes called an extreme value. When you graph an outlier, it will appear not to fit the pattern of the graph. Some outliers are due to mistakes (for example, writing down 50 instead of 500), while others may indicate that something unusual is happening. Outliers are present far from the least squares line in the vertical direction. They have large "errors," where the "error" or residual is the...
4.4K
Statistical Analysis: Overview01:11

Statistical Analysis: Overview

8.1K
When we take repeated measurements on the same or replicated samples, we will observe inconsistencies in the magnitude. These inconsistencies are called errors. To categorize and characterize these results and their errors, the researcher can use statistical analysis to determine the quality of the measurements and/or suitability of the methods.
One of the most commonly used statistical quantifiers is the mean, which is the ratio between the sum of the numerical values of all results and the...
8.1K
Prediction Intervals01:03

Prediction Intervals

2.4K
The interval estimate of any variable is known as the prediction interval. It helps decide if a point estimate is dependable.
However, the point estimate is most likely not the exact value of the population parameter, but close to it. After calculating point estimates, we construct interval estimates, called confidence intervals or prediction intervals. This prediction interval comprises a range of values unlike the point estimate and is a better predictor of the observed sample value, y. 
2.4K
Statistical Significance01:50

Statistical Significance

20.4K
Once data is collected from both the experimental and the control groups, a statistical analysis is conducted to find out if there are meaningful differences between the two groups. A statistical analysis determines how likely any difference found is due to chance (and thus not meaningful). In psychology, group differences are considered meaningful, or significant, if the odds that these differences occurred by chance alone are 5 percent or less. Stated another way, if we repeated this...
20.4K
Interpretation of Confidence Intervals01:19

Interpretation of Confidence Intervals

6.6K
A confidence interval is a better estimate of the population than a point estimate, as it uses a range of values from a sample instead of a single value.
Confidence intervals have confidence coefficients that are crucial for their interpretation. The most common confidence coefficients are 0.90, 0.95, and 0.99, which can be written as percentages–90%, 95%, and 99%, respectively.
Suppose a person calculates a confidence interval with a confidence coefficient of 0.95. In that case, they can...
6.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From Consensus to Regulatory End Point: Establishing Reference Standards as a Critical Step for Artificial Intelligence Software as Medical Devices.

Ophthalmology·2026
Same author

A SEQUENTIAL SIGNIFICANCE TEST FOR TREATMENT BY COVARIATE INTERACTIONS.

Statistica Sinica·2026
Same author

Clinical agents fail silently on patient identity.

International journal of medical informatics·2026
Same author

AI-induced never-skilling in medical education.

Nature medicine·2026
Same author

The evolving landscape of large language models and non-large language models in health care.

npj health systems·2026
Same author

RELEAP: reinforcement-enhanced label-efficient active phenotyping for electronic health records.

JAMIA open·2026
Same journal

Zero-shot reconstruction of mutant spatial transcriptomes.

Patterns (New York, N.Y.)·2026
Same journal

Dendritic nonlinearities mitigate communication costs.

Patterns (New York, N.Y.)·2026
Same journal

Erratum: Agentic AI as a coordination paradigm in digital health and agri-food systems.

Patterns (New York, N.Y.)·2026
Same journal

Spacing effect improves generalization in biological and artificial systems.

Patterns (New York, N.Y.)·2026
Same journal

A multi-modal foundation model for brain disease diagnosis and medical imaging.

Patterns (New York, N.Y.)·2026
Same journal

DuoMod-Net: Logarithmic balancing and geometric refinement for imbalanced semi-supervised medical image segmentation.

Patterns (New York, N.Y.)·2026
See all related articles

Related Experiment Video

Updated: Sep 25, 2025

Using Informational Connectivity to Measure the Synchronous Emergence of fMRI Multi-voxel Information Across Time
07:12

Using Informational Connectivity to Measure the Synchronous Emergence of fMRI Multi-voxel Information Across Time

Published on: July 1, 2014

12.4K

Shapley variable importance cloud for interpretable machine learning.

Yilin Ning1, Marcus Eng Hock Ong2,3,4, Bibhas Chakraborty1,2,5,6

  • 1Centre for Quantitative Medicine, Duke-NUS Medical School, 8 College Road, Singapore 169857, Singapore.

Patterns (New York, N.Y.)
|April 25, 2022
PubMed
Summary
This summary is machine-generated.

This study introduces Shapley variable importance clouds, extending machine learning interpretability beyond single models. This approach quantifies uncertainty for more reliable insights in complex prediction tasks.

Keywords:
Shapley valueexplainable artificial intelligenceexplainable machine learninginterpretable machine learningvariable importance cloud

More Related Videos

Author Spotlight: IntelliSleepScorer — A High-Accuracy, Accessible GUI Software for Automated Sleep Stage Scoring in Mice and its Application in Psychiatric Research
04:54

Author Spotlight: IntelliSleepScorer — A High-Accuracy, Accessible GUI Software for Automated Sleep Stage Scoring in Mice and its Application in Psychiatric Research

Published on: November 8, 2024

672
Surface Mapping of Earth-like Exoplanets using Single Point Light Curves
06:48

Surface Mapping of Earth-like Exoplanets using Single Point Light Curves

Published on: May 10, 2020

3.7K

Related Experiment Videos

Last Updated: Sep 25, 2025

Using Informational Connectivity to Measure the Synchronous Emergence of fMRI Multi-voxel Information Across Time
07:12

Using Informational Connectivity to Measure the Synchronous Emergence of fMRI Multi-voxel Information Across Time

Published on: July 1, 2014

12.4K
Author Spotlight: IntelliSleepScorer — A High-Accuracy, Accessible GUI Software for Automated Sleep Stage Scoring in Mice and its Application in Psychiatric Research
04:54

Author Spotlight: IntelliSleepScorer — A High-Accuracy, Accessible GUI Software for Automated Sleep Stage Scoring in Mice and its Application in Psychiatric Research

Published on: November 8, 2024

672
Surface Mapping of Earth-like Exoplanets using Single Point Light Curves
06:48

Surface Mapping of Earth-like Exoplanets using Single Point Light Curves

Published on: May 10, 2020

3.7K

Area of Science:

  • Machine Learning
  • Explainable AI
  • Statistical Inference

Background:

  • Current interpretable machine learning focuses on explaining single, optimized models.
  • Shapley Additive Explanations (SHAP) provides local and global model explanations.
  • Existing methods may yield biased inference when applied to a single model.

Purpose of the Study:

  • To extend global interpretability methods to a set of 'good enough' models.
  • To introduce a novel Shapley variable importance cloud for robust model assessment.
  • To quantify uncertainty in importance measures for formal statistical inference.

Main Methods:

  • Developed Shapley variable importance clouds by pooling Shapley values from multiple relevant models.
  • Quantified uncertainty explicitly within the importance measures.
  • Created visualizations to highlight uncertainty and its impact on practical inference.

Main Results:

  • The Shapley variable importance cloud provides an overall importance measure by integrating information across models.
  • Explicit quantification of uncertainty supports formal statistical inference.
  • Demonstrated reduced bias in inference compared to single-model SHAP assessments in recidivism and clinical data experiments.

Conclusions:

  • The Shapley variable importance cloud offers a more comprehensive and reliable approach to model interpretability.
  • This method complements existing SHAP assessments, mitigating potential biases.
  • The approach enhances the practical utility of interpretable machine learning in real-world applications.