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miR-874: An Important Regulator in Human Diseases

Qiudan Zhang1,2, Chenming Zhong2, Qianqian Yan2

  • 1School of Medicine, Zhejiang University City College, Hangzhou, China.

Frontiers in Cell and Developmental Biology
|April 25, 2022
PubMed

Insights

MicroRNA-874 (miR-874) dysfunction is linked to cancer development and impacts chemotherapy efficacy. This microRNA shows promise as a biomarker for cancer diagnosis and prognosis.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • MicroRNA-874 (miR-874) is located at chromosome 5q31.2, a region frequently deleted in various cancers.
  • Downregulation of miR-874 is observed in 22 cancer types and aberrant expression in 18 non-cancer diseases.
  • miR-874 dysfunction is associated with cancer diagnosis, prognosis, and chemotherapy drug efficacy.

Purpose of the Study:

  • To review the molecular functions of miR-874 in cancer biological processes.
  • To highlight the role of miR-874 in tumorigenesis, cell survival, apoptosis, and differentiation.
  • To reveal the potential of miR-874 as a cancer biomarker for diagnosis and prognosis.

Main Methods:

  • Literature review of studies on miR-874.
  • Analysis of miR-874's involvement in ceRNA networks (long non-coding RNAs, circular RNAs).
  • Examination of miR-874's regulation of key signaling pathways (Wnt/β-catenin, Hippo, PI3K/AKT, JAK/STAT, Hedgehog).

Main Results:

  • miR-874 participates in the ceRNA network, influencing cancer and non-cancer diseases.
  • miR-874 regulates multiple critical signaling pathways involved in cancer progression.
  • The review consolidates evidence for miR-874's roles in tumor cell biology.

Conclusions:

  • miR-874 is a significant factor in tumor cell survival, apoptosis, differentiation, and tumorigenesis.
  • miR-874 holds value as a biomarker for cancer diagnosis and prognosis.
  • Further research into miR-874's clinical application for chemotherapy resistance is warranted.
Keywords:
cancerceRNAdiagnosismiR-874non-cancerpathwayprognosistumor suppressor

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