Related Experiment Video
Updated: Sep 25, 2025
10:40
CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
Published on: April 25, 2022
2.5K
miR-874: An Important Regulator in Human Diseases
Qiudan Zhang1,2, Chenming Zhong2, Qianqian Yan2
1School of Medicine, Zhejiang University City College, Hangzhou, China.
Frontiers in Cell and Developmental Biology
|April 25, 2022
Summary
MicroRNA-874 (miR-874) dysfunction is linked to cancer development and impacts chemotherapy efficacy. This microRNA shows promise as a biomarker for cancer diagnosis and prognosis.
Area of Science:
- Molecular Biology
- Genetics
- Oncology
Background:
- MicroRNA-874 (miR-874) is located at chromosome 5q31.2, a region frequently deleted in various cancers.
- Downregulation of miR-874 is observed in 22 cancer types and aberrant expression in 18 non-cancer diseases.
- miR-874 dysfunction is associated with cancer diagnosis, prognosis, and chemotherapy drug efficacy.
Purpose of the Study:
- To review the molecular functions of miR-874 in cancer biological processes.
- To highlight the role of miR-874 in tumorigenesis, cell survival, apoptosis, and differentiation.
- To reveal the potential of miR-874 as a cancer biomarker for diagnosis and prognosis.
Main Methods:
- Literature review of studies on miR-874.
- Analysis of miR-874's involvement in ceRNA networks (long non-coding RNAs, circular RNAs).
- Examination of miR-874's regulation of key signaling pathways (Wnt/β-catenin, Hippo, PI3K/AKT, JAK/STAT, Hedgehog).
Main Results:
- miR-874 participates in the ceRNA network, influencing cancer and non-cancer diseases.
- miR-874 regulates multiple critical signaling pathways involved in cancer progression.
- The review consolidates evidence for miR-874's roles in tumor cell biology.
Conclusions:
- miR-874 is a significant factor in tumor cell survival, apoptosis, differentiation, and tumorigenesis.
- miR-874 holds value as a biomarker for cancer diagnosis and prognosis.
- Further research into miR-874's clinical application for chemotherapy resistance is warranted.
Related Concept Videos
02:23Master Transcription Regulators
7.1K
Master transcription regulators are regulatory proteins that are predominantly responsible for regulating the expression of multiple genes. Often these genes work in concert to drive a complex process. Activation of a master transcription regulator can lead to a cascade of transcriptional activation necessary for that outcome. These regulators can directly bind to the regulatory sequences of the various genes involved, or they can indirectly regulate transcription by binding to regulatory...
7.1K
01:31Regulation of the Unfolded Protein Response
2.6K
Inositol-requiring kinase one or IRE1 is the most conserved eukaryotic unfolded protein response (UPR) receptor. It is a type I transmembrane protein kinase receptor with a distinctive site-specific RNase activity. As the binding mechanics of the misfolded proteins with the N-terminal domain of IRE-1 are unclear, three binding models — direct, indirect, and allosteric -- are proposed for receptor activation. Nevertheless, it is known that once a misfolded protein associates with IRE1, it...
2.6K
02:23Abnormal Proliferation
4.6K
Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
01:22MicroRNAs
3.1K
MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.1K
03:03mTOR Signaling and Cancer Progression
3.9K
The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
The mTOR pathway or the...
3.9K
01:15Receptor Downregulation in MVBs
2.2K
Multivesicular bodies (MVBs) are mature endosomes that sort ubiquitinated proteins and then fuse with lysosomes to degrade the sorted proteins. Epidermal growth factor (EGF) and its receptor (EGFR) form a complex that can be internalized through endocytosis, sorted into an MVB, and later degraded.
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
The EGFR can initiate signaling pathways that lead to cell proliferation, migration, and differentiation. Overexpression of EGFR stimulates cells to proliferate. Excessive EGFR...
2.2K