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Roles of Embryonic Lethal Abnormal Vision-Like RNA Binding Proteins in Cancer and Beyond

Haijian Cai1, Dandan Zheng1, Yizhu Yao1

  • 1The First Affiliated Hospital, Wenzhou Medical University, Wenzhou, China.

Frontiers in Cell and Developmental Biology
|April 25, 2022
PubMed

Insights

Embryonic lethal abnormal vision-like (ELAVL) proteins regulate gene expression by binding to RNA. This review explores their roles in both mRNA and non-coding RNA interactions across various physiological and pathological processes.

Area of Science:

  • Molecular Biology
  • Genetics
  • Cancer Biology

Background:

  • Embryonic lethal abnormal vision-like (ELAVL) proteins are RNA-binding proteins crucial for nervous system development.
  • ELAVL proteins are implicated in various cancers by stabilizing mRNAs, making them potential therapeutic targets.
  • Emerging research indicates ELAVL proteins also interact with non-coding RNAs.

Purpose of the Study:

  • To review the multifaceted roles of the ELAVL protein family.
  • To summarize interactions between ELAVL proteins and both messenger RNAs (mRNAs) and non-coding RNAs.
  • To elucidate the involvement of ELAVL proteins in diverse physiological and pathological conditions.

Main Methods:

  • Literature review of existing studies on ELAVL proteins.
  • Analysis of research on ELAVL protein interactions with mRNA 3'-untranslated regions.
  • Synthesis of findings on ELAVL protein involvement in oncogenesis and other biological processes.

Main Results:

  • ELAVL proteins bind to specific mRNA sequences, influencing their stability and translation.
  • Evidence suggests ELAVL proteins interact with various non-coding RNAs, impacting gene regulation.
  • Dysregulation of ELAVL proteins is linked to the progression of multiple cancer types.

Conclusions:

  • ELAVL proteins are key regulators of gene expression through interactions with both coding and non-coding RNAs.
  • Understanding these interactions is vital for developing targeted cancer therapies.
  • ELAVL proteins play significant roles in both normal physiology and disease pathogenesis.
Keywords:
ELAVL proteinsRNA binding proteinscancersnon-coding RNAspost-transcriptional regulation

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