Semiconductor Polymer with Strong NIR-II Absorption for Photoacoustic Imaging and Photothermal Therapy

Semiconductor polymers have several featured advantages, such as easily tunable optical properties, high light harvesting, good photostability, etc. However, semiconductor polymers with desirable NIR-II absorbance for the applications of both NIR-II photoacoustic (PA) imaging and photothermal therapy (PTT) are still lacking. Herein, we synthesized a donor-acceptor (D-A) type semiconductor polymer PTPTQ with thiophene (TP) as the electron donor and thiadiazoloquinoxaline (TQ) as the acceptor. PTPTQ had a brushlike topological structure with two poly(ethylene glycol) (PEG) chains (2000 Da) in each repeating unit. Such an intriguing structure endowed it with high hydrophilicity, good biocompatibility, and prominent passive tumor targeting ability. PTPTQ exhibited strong absorption in 600-1800 nm and good photostability. Its photothermal conversion efficiency was determined to be about 41.36%, which rendered it excellent properties in NIR-II PA imaging and PTT. By using PTPTQ as a PTT agent, the mouse tumor models can be eradicated. Taken together, the overall properties of PTPTQ make it promising as a tumor theranostic agent.